PAX8 Antikörper (Paired Box 8)

Details for Product anti-PAX8 Antibody No. ABIN966806, Anbieter: Anmelden zum Anzeigen
Antigen
  • PAX8
  • XPax-8
  • XPax8
  • pax-8
  • PAX-8
  • Pax-8
  • paired box 8
  • paired box gene 8
  • PAX8
  • pax8
  • Pax8
Reaktivität
Human
210
44
43
13
9
9
8
7
5
4
3
2
1
Wirt
Maus
91
83
36
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser PAX8 Antikörper ist unkonjugiert
9
9
6
6
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
Applikation
ELISA, Western Blotting (WB)
181
92
62
58
54
49
41
25
4
3
3
2
1
1
1
1
1
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Purified recombinant fragment of human PAX8 expressed in E. Coli.
Klon 2D4
Isotyp IgG1
Reinigung Ascitic fluid
Andere Bezeichnung PAX8 (PAX8 Antibody Abstract)
Hintergrund This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas.
Tissue specificity: Expressed in the excretory system, thyroid gland and Wilms tumors.ABCAM: This protein is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Alternative splicing in the gene by inclusion or exclusion of exons 7 and/or 8 has produced several known products but the biological significance of the variants is unknown. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells.
Synonyms: PAX8
Molekulargewicht 60kDa
Gen-ID 7846
Forschungsgebiet Chromatin and Nuclear Signaling, Transcription Factors
Pathways Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation
Applikationshinweise Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Produkt verwendet in: McKnight, Cohen, Siddiqui: "Utility of paired box gene 8 (PAX8) expression in fluid and fine-needle aspiration cytology: an immunohistochemical study of metastatic ovarian serous carcinoma." in: Cancer cytopathology, Vol. 118, Issue 5, pp. 298-302, 2010 (PubMed).

Chia, Sharifah, Reena, Zubaidah, Clarence-Ko, Rohaizak, Naqiyah, Srijit, Hisham, Asmiati, Rafie: "Fluorescence in situ hybridization analysis using PAX8- and PPARG-specific probes reveals the presence of PAX8-PPARG translocation and 3p25 aneusomy in follicular thyroid neoplasms." in: Cancer genetics and cytogenetics, Vol. 196, Issue 1, pp. 7-13, 2009 (PubMed).

Allgemeine Veröffentlichungen Ramos, Nesi-França, Boldarine, Pereira, Chiamolera, Camacho, Graf, de Lacerda, Carvalho, Maciel: "Clinical and molecular analysis of thyroid hypoplasia: a population-based approach in southern Brazil." in: Thyroid : official journal of the American Thyroid Association, Vol. 19, Issue 1, pp. 61-8, 2009 (PubMed).

Haben Sie etwas anderes gesucht?