MAP2K5 Antikörper (Mitogen-Activated Protein Kinase Kinase 5) (AA 311-315)

Details for Product anti-MAP2K5 Antibody No. ABIN871696, Anbieter: Anmelden zum Anzeigen
Antigen
  • Mek5
  • HsT17454
  • MAPKK5
  • MEK5
  • PRKMK5
  • AI324775
  • AI428457
  • Mapkk5
  • Prkmk5
  • fb73f02
  • wu:fb73f02
  • zgc:172137
  • ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5
  • ATMAP2K_ALPHA
  • ATMEK5
  • ATMKK5
  • MAP KINASE KINASE 5
  • MAP kinase kinase 5
  • MAP2K_A
  • mitogen activated protein kinase kinase 5
  • mitogen-activated protein kinase kinase 5
  • Map2k5
  • MAP2K5
  • map2k5
  • MKK5
Alternativen
anti-Human MAP2K5 Antikörper für Immunofluorescence (fixed cells)
Epitop
AA 311-315
33
30
15
15
15
15
14
11
11
9
6
6
6
5
4
4
3
2
2
2
1
1
1
1
1
1
Reaktivität
Human, Ratte (Rattus), Maus
168
88
81
11
7
7
6
4
3
3
3
3
2
2
2
2
1
1
Wirt
Kaninchen
162
16
Klonalität
Polyklonal
Konjugat
Dieser MAP2K5 Antikörper ist unkonjugiert
9
9
9
5
5
5
5
5
5
5
5
5
5
4
4
4
4
Applikation
Western Blotting (WB)
110
64
47
28
25
22
4
3
2
1
1
1
Optionen
Hersteller
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Immunogen Peptide sequence around AA 311-315 (K-T-Y-V-G ) derived from Rat MEK5. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Spezifität The antibody detects endogenous level of total MEK5 protein.
Reinigung Affinity purified
Andere Bezeichnung MEK5 (MAP2K5 Antibody Abstract)
Hintergrund A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phospho-rylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resem-bles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphory-late ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.
Molekulargewicht 49 kDa
Gen-ID 29568
NCBI Accession NP_001029
UniProt Q62862
Forschungsgebiet Cancer, Kinases/Phosphatases
Pathways MAPK Signalweg, Neurotrophin Signalübertragung
Applikationshinweise Western blotting: 1:500
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Allgemeine Veröffentlichungen Holland, Suzanne, Campbell, Noselli, Cooper: "MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous." in: The Journal of biological chemistry, Vol. 272, Issue 40, pp. 24994-8, 1997 (PubMed).

Tournier, Whitmarsh, Cavanagh, Barrett, Davis: "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 14, pp. 7337-42, 1997 (PubMed).

Han, Lee, Jiang, Li, Feng, Ulevitch: "Characterization of the structure and function of a novel MAP kinase kinase (MKK6)." in: The Journal of biological chemistry, Vol. 271, Issue 6, pp. 2886-91, 1996 (PubMed).

Jiang, Chen, Li, Guo, Gegner, Lin, Han: "Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)." in: The Journal of biological chemistry, Vol. 271, Issue 30, pp. 17920-6, 1996 (PubMed).