Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) Antikörper

Details zu Produkt Nr. ABIN723725, Anbieter: Anmelden zum Anzeigen
Antigen
  • erk1/2
  • mitogen-activated protein kinase
  • erk1/2
Epitop
AA 330-358
129
127
35
34
30
19
18
15
15
15
15
14
12
9
9
9
9
8
6
5
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
421
320
304
57
23
15
9
8
8
7
7
6
5
5
3
3
2
2
2
1
1
1
1
Wirt
Kaninchen
349
78
7
Klonalität
Polyklonal
Konjugat
Unkonjugiert
12
11
11
10
7
7
7
7
6
6
6
6
6
6
2
2
2
2
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
305
114
83
77
59
56
46
42
16
10
6
4
4
4
2
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen KLH conjugated synthetic peptide derived from mouse ERK2
Isotyp IgG
Reinigung Purified by Protein A.
Andere Bezeichnung ERK1 + ERK2 (MAPK1/3 Antibody Abstract)
Hintergrund

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Subcellular location: Cytoplasm, Nucleus

Synonyms: Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, Mapk1, Erk2, Mapk, Prkm1

Gen-ID 26413
UniProt P63085
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
Immunofluorescence (IF) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) Formalin-fixed and paraffin-embedded rat brain labeled with Anti-ERK2/MAPK1 Polyclona...
Immunofluorescence (IF) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) Formalin-fixed and paraffin-embedded rat brain labeled with Anti-ERK2/MAPK1 Polyclona...
Immunohistochemistry (IHC) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) Formalin-fixed and paraffin embedded rat hippocampus labeled with Anti-ERK2/MAPK1 Pol...
SDS-PAGE (SDS) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) L1 rat brain, L2 rat heart lysates probed (ABIN723725) at 1:200 in 4 °C. Followed by ...
Immunohistochemistry (IHC) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-ERK2/MAPK...
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 330-358) antibody (ABIN723725) Mouse placenta lysates probed with ERK1 + ERK2 Polyclonal Antibody, unconjugated at ...
Produkt verwendet in: Chu, Zhao, Feng, Zhang, Liu, Cheng, Li, Shen, Cao, Li, Min: "MicroRNA-126 participates in lipid metabolism in mammary epithelial cells." in: Molecular and cellular endocrinology, Vol. 454, pp. 77-86, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Human).

Sun, Wang, Fu, Chen, Wang, Li, Xing, Li: "Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice." in: BioMed research international, Vol. 2015, pp. 139451, 2015 (PubMed).

Sun, Fu, Liu, Wang, Huo, Guo, Gao, Li, Hu: "Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice." in: Drug design, development and therapy, Vol. 9, pp. 6327-42, 2015 (PubMed).

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