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BRD8 Antikörper (AA 331-430)

BRD8 Reaktivität: Human, Ratte WB, ELISA, IHC (p), IF (p), IHC (fro), IF (cc) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN716951
  • Target Alle BRD8 Antikörper anzeigen
    BRD8 (Bromodomain Containing 8 (BRD8))
    Bindungsspezifität
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 331-430
    Reaktivität
    • 24
    • 10
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human, Ratte
    Wirt
    • 23
    • 2
    Kaninchen
    Klonalität
    • 23
    • 2
    Polyklonal
    Konjugat
    • 14
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BRD8 Antikörper ist unkonjugiert
    Applikation
    • 11
    • 7
    • 7
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc))
    Kreuzreaktivität
    Human, Ratte
    Homologie
    Mouse,Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human BRD8
    Isotyp
    IgG
    Top Product
    Discover our top product BRD8 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    BRD8 (Bromodomain Containing 8 (BRD8))
    Andere Bezeichnung
    Brd8 (BRD8 Produkte)
    Synonyme
    SMAP antikoerper, SMAP2 antikoerper, p120 antikoerper, 2610007E11Rik antikoerper, 4432404P07Rik antikoerper, bromodomain containing 8 antikoerper, BRD8 antikoerper, Brd8 antikoerper
    Hintergrund

    Synonyms: SMAP, p120, SMAP2, Bromodomain-containing protein 8, Skeletal muscle abundant protein, Skeletal muscle abundant protein 2, Thyroid hormone receptor coactivating protein of 120 kDa, TrCP120, BRD8

    Background: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

    Gen-ID
    10902
    UniProt
    Q9H0E9
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