BRD8 Antikörper (AA 641-859)

Produktnummer ABIN7145820

Produktdetails anti-BRD8 Antikörper

Target: BRD8 (Bromodomain Containing 8 (BRD8))

Bindungsspezifität: AA 641-859

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRD8 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Bromodomain-containing protein 8 protein (641-859AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BRD8

Target: BRD8 (Bromodomain Containing 8 (BRD8))

Andere Bezeichnung: BRD8 (BRD8 Produkte)

Synonyme: SMAP antikoerper, SMAP2 antikoerper, p120 antikoerper, 2610007E11Rik antikoerper, 4432404P07Rik antikoerper, bromodomain containing 8 antikoerper, BRD8 antikoerper, Brd8 antikoerper

Hintergrund:

Background: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Aliases: BRD8 antibody, SMAP antibody, SMAP2 antibody, Bromodomain-containing protein 8 antibody, Skeletal muscle abundant protein antibody, Skeletal muscle abundant protein 2 antibody, Thyroid hormone receptor coactivating protein of 120 kDa antibody, TrCP120 antibody, p120 antibody

UniProt: Q9H0E9