CYP1A2 Antikörper (AA 255-282)

Produktnummer ABIN655272

Produktdetails anti-CYP1A2 Antikörper

Target: CYP1A2 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2))

Bindungsspezifität: AA 255-282

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYP1A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CYP1A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-282 amino acids from the Central region of human CYP1A2.

Klon: RB16939

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-CYP1A2 Antikörper (ABIN655272)

Sriwattanapong, Slocum, Chawanthayatham, Fedeles, Egner, Groopman, Satayavivad, Croy, Essigmann: "Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 160, Issue 1, pp. 173-179, (2018) (PubMed).

Okamatsu, Kawakami, Komatsu, Kitazawa, Uno, Teraoka: "Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 47, Issue 11, pp. 951-961, (2017) (PubMed).

Details zu CYP1A2

Target: CYP1A2 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2))

Andere Bezeichnung: CYP1A2 (CYP1A2 Produkte)

Synonyme: CP12 antikoerper, P3-450 antikoerper, P450(PA) antikoerper, CYP1A2 antikoerper, CYPIA2 antikoerper, P450-PM4 antikoerper, Cyp1a1 antikoerper, P450-3 antikoerper, CYPD45 antikoerper, P-450d antikoerper, RATCYPD45 antikoerper, CYP1A5 antikoerper, CP450 antikoerper, CYP-IA2 antikoerper, cytochrome P450 family 1 subfamily A member 2 antikoerper, cytochrome P450 1A2 antikoerper, cytochrome P450 LM4 antikoerper, cytochrome P450, family 1, subfamily A, polypeptide 2 antikoerper, cytochrome P450, family 1, subfamily a, polypeptide 2 antikoerper, cytochrome P450 1A2-like antikoerper, CYP1A2 antikoerper, LOC100328937 antikoerper, Cyp1a2 antikoerper, VDBG_06455 antikoerper, LOC101825565 antikoerper, LOC102130662 antikoerper

Hintergrund: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown, however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.

Molekulargewicht: 58407

Gen-ID: 1544

NCBI Accession: NP_000752

UniProt: P05177