UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 4 (GalNAc-T4) (GALNT4) (AA 93-120), (N-Term) Antikörper

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Antigen
  • GALNAC-T4
  • GALNACT4
  • AV011803
  • polypeptide N-acetylgalactosaminyltransferase 4
  • polypeptide N-acetylgalactosaminyltransferase 4 L homeolog
  • GALNT4
  • galnt4.L
  • Galnt4
Epitop
AA 93-120, N-Term
11
9
9
4
2
1
1
1
1
Reaktivität
Human
40
13
13
4
3
3
2
2
1
1
Wirt
Kaninchen
39
1
Klonalität (Klon)
Polyklonal ()
Konjugat
Unkonjugiert
2
2
2
2
2
2
Applikation
Flow Cytometry (FACS), Western Blotting (WB)
36
20
17
6
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This GALNT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 AA from the N-terminal region of human GALNT4.
Klon RB23943
Isotyp Ig
Spezifität This GALNT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-128 amino acids from the N-terminal region of human GALNT4.
Homologie Mouse (Murine)
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Andere Bezeichnung GALNT4 (GALNT4 Antibody Abstract)
Hintergrund This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon.
Synonyms: Polypeptide N-acetylgalactosaminyltransferase 4,GALNT4,
Molekulargewicht 66608 DA
Gen-ID 8693
NCBI Accession NP_003765
UniProt Q8N4A0
Forschungsgebiet Cell Signaling, Protein Modifications, Cell Structure
Applikationshinweise WB = 1:1000, FACS = 1:10-50
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 4 (GalNAc-T4) (GALNT4) (AA 93-120), (N-Term) antibody (ABIN654149) GALNT4 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane)...
Flow Cytometry (FACS) image for anti-UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 4 (GalNAc-T4) (GALNT4) (AA 93-120), (N-Term) antibody (ABIN654149) GALNT4 Antibody (N-term) flow cytometric analysis of Hela cells (right histogram) co...
Allgemeine Veröffentlichungen Bennett, Hassan, Mandel, Mirgorodskaya, Roepstorff, Burchell, Taylor-Papadimitriou, Hollingsworth, Merkx, van Kessel, Eiberg, Steffensen, Clausen: "Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat." in: The Journal of biological chemistry, Vol. 273, Issue 46, pp. 30472-81, 1998 (PubMed).

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