SLC7A11 Antikörper (Internal Region)

Produktnummer ABIN374804

Produktdetails anti-SLC7A11 Antikörper

Target: SLC7A11 (Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11))

Bindungsspezifität: Internal Region

Reaktivität: Human, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SLC7A11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Sequenz: C-KGQTQNFKDA FSGRD

Spezifität: This antibody detects XCT / SLC7A11.

Kreuzreaktivität (Details): Species reactivity (expected):Canine (Dog).
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide from the internal region of the protein sequence according to NP_055146.1 Genename: SLC7A11

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: antibody detection limit dilution 1: 128000. Western blot: Approx 50 kDa band observed in Human Spleen and Human Thymus lysates(calculated MW of 55.0 kDa according to NP_055146.1). Recommended concentration: 0.02-0.06 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SLC7A11

Target: SLC7A11 (Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 (SLC7A11))

Andere Bezeichnung: XCT / SLC7A11 (SLC7A11 Produkte)

Synonyme: SLC7A11 antikoerper, DKFZp468E122 antikoerper, CCBR1 antikoerper, xCT antikoerper, 9930009M05Rik antikoerper, AI451155 antikoerper, sut antikoerper, solute carrier family 7 member 11 antikoerper, solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 antikoerper, solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 antikoerper, SLC7A11 antikoerper, Slc7a11 antikoerper

Hintergrund: Mammalian amino acid transport systems consist of a large variety of transporters. The amino acid transporter, cystine/glutamic acid transporter xCT, for system xc has been proposed to be responsible for the cystine transport through the plasma membrane. System xc mediates an amino acid exchange and prefers cystine and glutamate as its substrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98) for its functional expression, and belongs to the family of amino acid transporters that associates with the type II membrane glycoproteins such as 4F2hc. In brain, it has been proposed that system xc is up-regulated in glial cells upon oxidative stress and plays an essential roles to protect neurons against oxidative stress. Recent studies have implicated xCT as a gateway that Kaposi's sarcoma herpesvirus (KSHV) uses to enter cells.Synonyms: Amino acid transport system xc, CCBR1, Calcium channel blocker resistance protein CCBR1, Cystine/glutamate transporter, Solute carrier family 7 member 11

Gen-ID: 23657

NCBI Accession: NP_055146

UniProt: Q9UPY5