INPP5E Antikörper (Middle Region)

Produktnummer ABIN5516992

Produktdetails anti-INPP5E Antikörper

Target: INPP5E (Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser INPP5E Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SLQEIPKSRG VLSSERGSPS SGGNPLSGVA SSSPNLPHRD AAVAGSSPRL

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human INPP5E

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu INPP5E

Target: INPP5E (Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E))

Andere Bezeichnung: INPP5E (INPP5E Produkte)

Synonyme: 1200002L24Rik antikoerper, 72kDa antikoerper, mKIAA0123 antikoerper, CORS1 antikoerper, CPD4 antikoerper, JBTS1 antikoerper, MORMS antikoerper, PPI5PIV antikoerper, PMPCA antikoerper, inositol polyphosphate-5-phosphatase E antikoerper, Inpp5e antikoerper, INPP5E antikoerper

Hintergrund: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome, a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alias Symbols: CPD4, CORS1, JBTS1, MORMS, PPI5PIV

Protein Size: 610

Gen-ID: 56623

NCBI Accession: NM_019892, NP_063945