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BACE2 Antikörper (N-Term)

BACE2 Reaktivität: Human, Ratte, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499395
  • Target Alle BACE2 Antikörper anzeigen
    BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
    Bindungsspezifität
    • 15
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 43
    • 32
    • 11
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 62
    • 2
    • 1
    Kaninchen
    Klonalität
    • 64
    • 1
    Polyklonal
    Konjugat
    • 29
    • 10
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BACE2 Antikörper ist unkonjugiert
    Applikation
    • 46
    • 31
    • 20
    • 13
    • 13
    • 11
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    BACE2 antibody was raised against a synthetic peptide corresponding to amino acids 44 to 59 of human BACE2.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    Human BACE2 (N-Terminus) Peptide
    Isotyp
    IgG
    Top Product
    Discover our top product BACE2 Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: BACE2 can be used for detection of BACE2 at 0.5 to 1 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
    Andere Bezeichnung
    BACE2 (BACE2 Produkte)
    Synonyme
    AEPLC antikoerper, ALP56 antikoerper, ASP1 antikoerper, ASP21 antikoerper, BAE2 antikoerper, CEAP1 antikoerper, DRAP antikoerper, 1110059C24Rik antikoerper, AI850424 antikoerper, ARP1 antikoerper, CDA13 antikoerper, beta-site APP-cleaving enzyme 2 antikoerper, BACE2 antikoerper, Bace2 antikoerper
    Hintergrund
    Accumulation of the amyloid-beta (alphabeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. alphabeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at beta-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)Synonyms: AEPLC, ALP56, ASP1, ASP21, Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-secretase 2, Beta-site APP-cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1
    Gen-ID
    25825
    UniProt
    Q9Y5Z0
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