BACE2 Produkte
(beta-Site APP-Cleaving Enzyme 2 (BACE2))
Kategorien
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte BACE2 Kategorien
BACE2 Antikörper
High quality antibodies with extensive validation data.
BACE2 ELISA Kits
Reliable ELISA kits for a wide range of species.
BACE2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene BACE2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (6)
Kat. Nr.
ABIN7434101
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Rat
Applikation
WB, IHC, IP, ICC
Validierungen
- (8)
Kat. Nr.
ABIN7438730
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (5)
Kat. Nr.
ABIN7265880
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene BACE2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6965162
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6965163
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN770620
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene BACE2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7121999
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346347
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN7194384
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren BACE2 Produkten
: "BACE-2 is overexpressed in Down's syndrome." in: Experimental neurology, Vol. 182, Issue 2, pp. 335-45, (2003) (PubMed).: "Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 31512-20, (2003) (PubMed).
: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).
: "The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region." in: FEBS letters, Vol. 468, Issue 1, pp. 59-64, (2000) (PubMed).
: "Expression analysis of BACE2 in brain and peripheral tissues." in: The Journal of biological chemistry, Vol. 275, Issue 27, pp. 20647-51, (2000) (PubMed).
: "BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 17, pp. 9712-7, (2000) (PubMed).
: "Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 4, pp. 1457-62, (1999) (PubMed).
: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, (1999) (PubMed).
: "A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma." in: Nature medicine, Vol. 3, Issue 8, pp. 917-21, (1997) (PubMed).
Synonyme und alternative Namen zu BACE2
beta-site APP-cleaving enzyme 2 (BACE2), beta-site APP-cleaving enzyme 2 (Bace2), 1110059C24Rik, AEPLC, AI850424, ALP56, ARP1, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAPBezeichner auf Proteinebene für BACE2
- 56 kDa aspartic-like protease
- Down syndrome region aspartic protease
- aspartyl protease 1
- beta-secretase 2
- beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
- memapsin-1
- membrane-associated aspartic protease 1
- theta-secretase
- transmembrane aspartic proteinase Asp1
- ASP1
- asp 1
- beta-site APP cleaving enzyme 2
- beta-site amyloid precursor protein cleaving enzyme 2
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