ATP6V1C1 Antikörper (N-Term)
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- Target Alle ATP6V1C1 Antikörper anzeigen
- ATP6V1C1 (ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Ratte, Maus, Kaninchen, Rind (Kuh), Hund, Pferd, Zebrafisch (Danio rerio), Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ATP6V1C1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- ldafvegvvk kvaqymadvl edskdkvqen llangvdlvt yitrfqwdma
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
- Produktmerkmale
- This is a rabbit polyclonal antibody against ATP6V1C1. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human ATP6V1C1
- Top Product
- Discover our top product ATP6V1C1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 382 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy." in: Oncotarget, Vol. 6, Issue 29, pp. 28057-70, (2015) (PubMed).
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V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy." in: Oncotarget, Vol. 6, Issue 29, pp. 28057-70, (2015) (PubMed).
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- Target
- ATP6V1C1 (ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1))
- Andere Bezeichnung
- ATP6V1C1 (ATP6V1C1 Produkte)
- Synonyme
- ATP6C antikoerper, ATP6D antikoerper, VATC antikoerper, Vma5 antikoerper, 1700025B18Rik antikoerper, U13839 antikoerper, vatC antikoerper, ATPase antikoerper, atp6v1c1 antikoerper, si:zc215i13.2 antikoerper, wu:fd12h05 antikoerper, atp6v1c1l antikoerper, zgc:92684 antikoerper, ATPase H+ transporting V1 subunit C1 antikoerper, ATPase, H+ transporting, lysosomal V1 subunit C1 antikoerper, ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 antikoerper, ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 L homeolog antikoerper, ATPase, H+ transporting, lysosomal, V1 subunit C1a antikoerper, ATPase, H+ transporting, lysosomal, V1 subunit C1b antikoerper, ATP6V1C1 antikoerper, Atp6v1c1 antikoerper, atp6v1c1 antikoerper, atp6v1c1.L antikoerper, atp6v1c1a antikoerper, atp6v1c1b antikoerper
- Hintergrund
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ATP6V1C1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ATP6C, ATP6D, FLJ20057, VATC, Vma5
Protein Interaction Partner: ATP6V1C1, IVNS1ABP, ATG7, DNM1L, TSN, STAT1, SNX2, SNX1, SHMT2, SHMT1, SARS, RDX, PAWR, NASP, IDE, GTF2A1, GSPT1, CTTN, PSMG3, ANP32E, TBC1D15, SNX6, VPS35, VPS29, LUC7L2, VTA1, ARFIP1, GSPT2, UBC, UBAC2, TXNDC17, MRPS35, CISD1, VASP, TYMS, SSR1, SRSF5, A
Protein Size: 382 - Molekulargewicht
- 42 kDa
- Gen-ID
- 528
- NCBI Accession
- NM_001695, NP_001686
- UniProt
- P21283
- Pathways
- Transition Metal Ion Homeostasis, Proton Transport
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