SNRPE Antikörper (Small Nuclear Ribonucleoprotein Polypeptide E) (AA 424-453)

Details for Product anti-SNRPE Antibody No. ABIN392249, Anbieter: Anmelden zum Anzeigen
Antigen
  • B-raf
  • HYPT11
  • SME
  • Sm-E
  • b-raf
  • sm-e
  • sme
  • SmE
  • snRNP-E
  • AL022645
  • C76690
  • zgc:56682
  • small nuclear ribonucleoprotein polypeptide E
  • small nuclear ribonucleoprotein polypeptide E L homeolog
  • small nuclear ribonucleoprotein E
  • SNRPE
  • snrpe.L
  • Snrpe
  • snrpe
Epitop
AA 424-453, Ser445
15
15
15
9
9
6
6
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
139
108
87
8
8
6
4
4
3
2
2
2
2
1
1
Wirt
Kaninchen
126
10
3
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser SNRPE Antikörper ist unkonjugiert
3
3
2
2
2
2
2
2
2
2
2
2
2
2
Applikation
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
91
64
44
30
30
22
10
9
8
3
2
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This B-RAF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 424-453 AA from human B-RAF.
Klon RB10940-RB17180
Isotyp Ig
Spezifität This B-RAF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S445 of human BRAF.
Homologie Chicken,Mouse (Murine)
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Andere Bezeichnung B-RAF (SNRPE Antibody Abstract)
Hintergrund BRAF, a member of the RAF subfamily of Ser/Thr protein kinases, is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It may play a role in the postsynaptic responses of hippocampal neurons. This cytoplasmic protein is expressed in brain and testis. Defects in BRAF are involved in a wide range of cancers including lung cancer and non-Hodgkin lymphoma (NHL). This protein contains 1 zinc-dependent phorbol-ester and DAG binding domain.
Synonyms: B-Raf proto-oncogene serine/threonine-protein kinase, p94, v-Raf murine sarcoma viral oncogene homolog B1
Molekulargewicht 84490 DA
Gen-ID 673
UniProt P15056
Forschungsgebiet Apoptosis/Necrosis, Protein Modifications, Cell Structure, Cancer, Neurology
Pathways Ribonucleoprotein Complex Subunit Organization, Hepatitis C
Applikationshinweise WB = 1:1000, IHC (p) = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE) (AA 424-453), (Ser445) antibody (ABIN392249) Western blot analysis of BRAF (arrow) using rabbit polyclonal BRAF Antibody (S445) (A...
Immunohistochemistry (IHC) image for anti-Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE) (AA 424-453), (Ser445) antibody (ABIN392249) Formalin-fixed and paraffin-embedded human brain tissue reacted with BRAF Antibody (S...
Allgemeine Veröffentlichungen Hingorani, Jacobetz, Robertson, Herlyn, Tuveson: "Suppression of BRAF(V599E) in human melanoma abrogates transformation." in: Cancer research, Vol. 63, Issue 17, pp. 5198-202, 2003 (PubMed).

Davies, Bignell, Cox, Stephens, Edkins, Clegg, Teague, Woffendin, Garnett, Bottomley, Davis, Dicks, Ewing, Floyd, Gray, Hall, Hawes, Hughes, Kosmidou, Menzies, Mould, Parker, Stevens, Watt, Hooper et al.: "Mutations of the BRAF gene in human cancer. ..." in: Nature, Vol. 417, Issue 6892, pp. 949-54, 2002 (PubMed).

Naoki, Chen, Richards, Sugarbaker, Meyerson: "Missense mutations of the BRAF gene in human lung adenocarcinoma." in: Cancer research, Vol. 62, Issue 23, pp. 7001-3, 2002 (PubMed).

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