MUC1 Antikörper (C-Term)
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- Target Alle MUC1 Antikörper anzeigen
- MUC1 (Mucin 1 (MUC1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser MUC1 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody recognizes Mucin 1 (MUC1/CA15-3/CA27-29).
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human.
- Produktmerkmale
- Synonyms: MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3, Polymorphic epithelial mucin,Tumor-associated mucin, Carcinoma-associated mucin, Tumor-associated epithelialmembrane antigen, Peanut-reactive urinary mucin, Breast carcinoma-associated antigenDF3
- Aufreinigung
- Purified
- Immunogen
- Synthetic Peptide derived from C-terminal sequence of Human CD227/Mucin-1.
- Klon
- G22-L
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product MUC1 Primärantikörper
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- Applikationshinweise
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Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- 20 mM Tris-HCl, pH 8.0 containing 20 mg/mL BSA as stabilizer and 0.05 % Sodium Azide as preservative
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
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Store the antibody (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - Haltbarkeit
- 12 months
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Expression of cyclooxygenase-2 and mucin 1 in colorectal cancer." in: Molecular and clinical oncology, Vol. 13, Issue 5, pp. 52, (2020) (PubMed).
: "MUC1 as a discriminator between endometrium from fertile and infertile patients with PCOS and endometriosis." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 12, pp. 5320-9, (2011) (PubMed).
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Expression of cyclooxygenase-2 and mucin 1 in colorectal cancer." in: Molecular and clinical oncology, Vol. 13, Issue 5, pp. 52, (2020) (PubMed).
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- Target
- MUC1 (Mucin 1 (MUC1))
- Andere Bezeichnung
- CD227 / Mucin-1 / MUC1 (MUC1 Produkte)
- Synonyme
- CA 15-3 antikoerper, CD227 antikoerper, EMA antikoerper, H23AG antikoerper, KL-6 antikoerper, MAM6 antikoerper, MCKD1 antikoerper, MUC-1 antikoerper, MUC-1/SEC antikoerper, MUC-1/X antikoerper, MUC1/ZD antikoerper, PEM antikoerper, PEMT antikoerper, PUM antikoerper, Muc-1 antikoerper, mucin 1, cell surface associated antikoerper, mucin 1, transmembrane antikoerper, MUC1 antikoerper, Muc1 antikoerper
- Hintergrund
- MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90 % breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Isoform 7 of MUC1 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling.Synonyms: Breast carcinoma-associated antigen DF3, CA 15-3, Carcinoma-associated mucin, DF3, EMA, Episialin, H23AG, MUC-1, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
- Gen-ID
- 4582
- UniProt
- P15941
- Pathways
- Negative Regulation of intrinsic apoptotic Signaling
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