MAP2K5 Antikörper (Mitogen-Activated Protein Kinase Kinase 5) (Ser149)

Details for Product anti-MAP2K5 Antibody No. ABIN360284, Anbieter: Anmelden zum Anzeigen
Antigen
  • Mek5
  • HsT17454
  • MAPKK5
  • MEK5
  • PRKMK5
  • AI324775
  • AI428457
  • Mapkk5
  • Prkmk5
  • fb73f02
  • wu:fb73f02
  • zgc:172137
  • ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5
  • ATMAP2K_ALPHA
  • ATMEK5
  • ATMKK5
  • MAP KINASE KINASE 5
  • MAP kinase kinase 5
  • MAP2K_A
  • mitogen activated protein kinase kinase 5
  • mitogen-activated protein kinase kinase 5
  • Map2k5
  • MAP2K5
  • map2k5
  • MKK5
Epitop
Ser149
33
32
15
15
15
15
14
11
9
9
6
6
5
4
4
4
3
3
2
2
2
1
1
1
1
1
1
Reaktivität
Human
169
90
83
11
7
7
6
4
3
3
3
3
2
2
2
2
1
1
Wirt
Kaninchen
164
16
Klonalität
Polyklonal
Konjugat
Dieser MAP2K5 Antikörper ist unkonjugiert
9
9
9
5
5
5
5
5
5
5
5
5
5
4
4
4
4
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
112
64
47
28
24
22
4
3
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S149 of human MAP2K5.
Isotyp Ig
Spezifität This antibody reacts to MAP2K5.
Reinigung Protein A column, followed by peptide affinity purification
Andere Bezeichnung MAP2K5 (MAP2K5 Antibody Abstract)
Hintergrund MAP2K5 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. It specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MAP2K5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation.Synonyms: Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MEK5, MKK5
Gen-ID 5607, 9606
UniProt Q13163
Forschungsgebiet Kinases/Phosphatases
Pathways MAPK Signalweg, Neurotrophin Signalübertragung
Applikationshinweise ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Bilder des Herstellers
 image for anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Ser149) antibody (ABIN360284) anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Ser149) antibody
 image for anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Ser149) antibody (ABIN360284) anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Ser149) antibody (Image 2)
Allgemeine Veröffentlichungen Raviv, Kalie, Seger: "MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation." in: Journal of cell science, Vol. 117, Issue Pt 9, pp. 1773-84, 2004 (PubMed).

English, Pearson, Hockenberry, Shivakumar, White, Cobb: "Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31588-92, 1999 (PubMed).

Kato, Kravchenko, Tapping, Han, Ulevitch, Lee: "BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C." in: The EMBO journal, Vol. 16, Issue 23, pp. 7054-66, 1998 (PubMed).

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