GABARAP Antikörper

Produktnummer ABIN349991

Produktdetails anti-GABARAP Antikörper

Target: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Reaktivität: Human, Maus, Ratte

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser GABARAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for GABARAP.

Immunogen: A synthetic peptide from human GABA(A) receptor-associated protein (GABARAP, MM46, FLC3B) conjugated to an immunogenic carrier protein has been used as the antigen. The antigen is homologous in rat and mouse.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Use at a concentration of 10-50 µg/ml.
The optimal working concentration should be determined by the end user.
Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu GABARAP

Target: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Andere Bezeichnung: GABARAP (GABARAP Produkte)

Synonyme: GABARAP antikoerper, ATG8A antikoerper, GABARAP-a antikoerper, MM46 antikoerper, gabarap antikoerper, mg:bb02b03 antikoerper, GABA type A receptor-associated protein antikoerper, gamma-aminobutyric acid receptor-associated protein antikoerper, GABA(A) receptor-associated protein a antikoerper, gamma-aminobutyric acid receptor associated protein antikoerper, GABARAP antikoerper, LOC5568843 antikoerper, Gabarap antikoerper, gabarapa antikoerper

Hintergrund: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. GABARAP belongs ot a large family of proteins that mediate intracellular membrane trafficking and/or fusion. GABARAP binds not only to GABA, type A but also to tubulin, gephrin, and ULK1. May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. It interacts with GPHN and NSF, interacts with GABRG2, beta-tubulin and ULK1.
Subcellular location: Intracytoplasmic membrane. Cytoplasm, cytoskeleton. Note: Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules.
Tissue specificity: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Also known as: GABA(A) receptor-associated protein, MM46, GABARAP.

Pathways: Autophagie