IKAP/p150 Antikörper

Produktnummer ABIN303006

Produktdetails anti-IKAP/p150 Antikörper

Target: IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IKAP/p150 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody residues 148-161 IHQDDFGESKFITV of IKAP.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections: 20 μg/mL. Western Blot: 1: 500 - 1: 1000. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu IKAP/p150

Target: IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))

Andere Bezeichnung: ELP1 / IKBKAP (ELP1 Produkte)

Synonyme: DYS antikoerper, ELP1 antikoerper, FD antikoerper, IKAP antikoerper, IKI3 antikoerper, TOT1 antikoerper, IKBKAP antikoerper, DKFZp469N1415 antikoerper, 3110040G09Rik antikoerper, 6030413P05 antikoerper, C78473 antikoerper, Elp1 antikoerper, Ikbkap antikoerper, elongator complex protein 1 antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein antikoerper, ielongator complex protein 1 S homeolog antikoerper, inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein antikoerper, ELP1 antikoerper, Elp1 antikoerper, IKBKAP antikoerper, elp1.S antikoerper, elp1 antikoerper, Ikbkap antikoerper

Hintergrund: IKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKa, IKKß, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD. At least two isoforms of IKAP are known two exist.Synonyms: Elongator complex protein 1, IKAP, IKK complex-associated protein, IkappaB kinase complex-associated protein, p150

Gen-ID: 8518

NCBI Accession: NP_003631

UniProt: O95163