IKAP/p150 Antikörper (C-Term)

Produktnummer ABIN499964

Der Kaninchen Polyklonal anti-IKAP/p150 Antikörper wird verwendet zum Nachweis von IKAP/p150 in Proben von Human und Maus. Er wurde validiert für WB, IF und EIA.

Kurzübersicht für IKAP/p150 Antikörper (C-Term) (ABIN499964)

Target: IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IKAP/p150 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-IKAP/p150 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to IKAP.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: IKAP antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human IKAP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 0.5 to 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu IKAP/p150

Target: IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))

Andere Bezeichnung: ELP1 / IKBKAP

Hintergrund: IKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKalpha, IKKbeta, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD. At least two isoforms of IKAP are known two exist.Synonyms: Elongator complex protein 1, IKAP, IKK complex-associated protein, IkappaB kinase complex-associated protein, p150

Gen-ID: 8518

UniProt: O95163