HLA-DMA Antikörper (N-Term)
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- Target Alle HLA-DMA Antikörper anzeigen
- HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
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Bindungsspezifität
- N-Term
- Reaktivität
- Human, Ratte, Kaninchen, Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser HLA-DMA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- GLSEAYDEDQ LFFFDFSQNT RVPRLPEFAD WAQEQGDAPA ILFDKEFCEW
- Homologie
- Dog: 77%, Human: 100%, Rabbit: 82%, Rat: 86%
- Produktmerkmale
- This is a rabbit polyclonal antibody against HLA-DMA. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human HLA-DMA
- Top Product
- Discover our top product HLA-DMA Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 261 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
- Andere Bezeichnung
- HLA-DMA (HLA-DMA Produkte)
- Synonyme
- RT1.Ma antikoerper, RT1.DMa antikoerper, HLA-DMA antikoerper, H-2Ma antikoerper, H2-Ma antikoerper, D6S222E antikoerper, DMA antikoerper, HLADM antikoerper, RING6 antikoerper, RT1 class II, locus DMa antikoerper, SLA-DM alpha chain antikoerper, major histocompatibility complex, class II, DM alpha antikoerper, histocompatibility 2, class II, locus DMa antikoerper, RT1-DMa antikoerper, SLA-DMA antikoerper, DLA-DMA antikoerper, H2-DMa antikoerper, HLA-DMA antikoerper
- Hintergrund
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HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Alias Symbols: D6S222E, DMA, HLADM, RING6
Protein Interaction Partner: B3GAT1, U2AF2, RUNX1, UBC, CD82, HLA-DRB1, HLA-DOA, HLA-DRA, HLA-DMB, CD74,
Protein Size: 261 - Molekulargewicht
- 29 kDa
- Gen-ID
- 3108
- NCBI Accession
- NM_006120, NP_006111
- UniProt
- Q31604
- Pathways
- Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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