PILRA Antikörper (N-Term)
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- Target Alle PILRA Antikörper anzeigen
- PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PILRA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- IPFSFYYPWE LATAPDVRIS WRRGHFHRQS FYSTRPPSIH KDYVNRLFLN
- Spezifität
- 100 % homologous to all four isoforms of human PILRA.
- Homologie
- Human: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against PILRA. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human PILRA
- Top Product
- Discover our top product PILRA Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 175 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))
- Andere Bezeichnung
- PILRA (PILRA Produkte)
- Synonyme
- PILRA antikoerper, FDF03 antikoerper, AV021745 antikoerper, RGD1562847 antikoerper, paired immunoglobin like type 2 receptor alpha antikoerper, paired immunoglobulin-like type 2 receptor alpha antikoerper, paired immunoglobin-like type 2 receptor alpha antikoerper, PILRA antikoerper, LOC489841 antikoerper, Pilra antikoerper
- Hintergrund
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Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Alias Symbols: FDF03
Protein Interaction Partner: DNPH1, SORBS1, PTPN6, PTPN11, FCAR,
Protein Size: 175 - Molekulargewicht
- 18 kDa
- Gen-ID
- 29992
- NCBI Accession
- NM_178273, NP_840057
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