DVL1 Antikörper (Dishevelled, Dsh Homolog 1 (Drosophila)) (C-Term)

Details for Product anti-DVL1 Antibody No. ABIN2779457, Anbieter: Anmelden zum Anzeigen
Antigen
  • Xdsh
  • dsh1
  • dvl-1
  • DVL
  • DVL1L1
  • DVL1P1
  • DSH
  • DVL-22
  • DVL1
  • DVL4
  • Dvl
  • mKIAA4029
  • DVL-1
  • dvl1
  • dvl2l
  • dishevelled segment polarity protein 1
  • dishevelled segment polarity protein 1 pseudogene 1
  • dishevelled, dsh homolog 1 (Drosophila)
  • dishevelled, dsh homolog 1b (Drosophila)
  • dvl1
  • Dvl1
  • DVL1
  • DVL1P1
  • dvl1b
Alternativen
anti-Human DVL1 Antikörper für Immunofluorescence (fixed cells)
Epitop
C-Term
15
14
10
10
9
4
3
3
3
3
3
2
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Schwein, Ratte (Rattus), Yeast
58
40
27
15
7
4
3
3
2
2
2
2
1
1
Wirt
Kaninchen
56
22
3
Klonalität
Polyklonal
Konjugat
Dieser DVL1 Antikörper ist unkonjugiert
7
7
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
68
45
17
16
13
9
6
1
1
Optionen
Hersteller
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Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human DVL1
Sequenz AAGAGGSGSE SDHTAPSGVG SSWRERPAGQ LSRGSSPRSQ ASATAPGLPP
Homologie Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rat: 86%, Yeast: 85%
Produktmerkmale This is a rabbit polyclonal antibody against DVL1. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Protein A purified
Andere Bezeichnung DVL1 (DVL1 Antibody Abstract)
Hintergrund DVL1 is a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 gene is a candidate for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.
Alias Symbols: DVL, MGC54245, DVL1L1
Protein Interaction Partner: NCK2, TRIM69, NUMA1, HUWE1, UBC, DVL2, WWOX, SIPA1, PSMA3, LRRK2, ITCH, HECW1, NEDD4, ANXA7, SDC4, NKD2, CYLD, SIRT1, CCDC88C, VANGL1, CXXC4, PPM1A, DYNLT1, HDHD2, BRD7, DAAM1, AXIN1, USP13, SMAD3, SMAD7, FRAT1, RAC1, DVL3, SMAD2, DVL1, SMAD4, CSNK1D, CSN
Protein Size: 670
Molekulargewicht 73 kDa
Gen-ID 1855
NCBI Accession NM_004421, NP_004412
Pathways WNT Signalweg, Synaptic Membrane, Skeletal Muscle Fiber Development
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 670 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-DVL1 Antikörper (Dishevelled, Dsh Homolog 1 (Drosophila)) (C-Term) (ABIN2779457) WB Suggested Anti-DVL1 Antibody Titration: 2.5ug/ml
Positive Control:
Allgemeine Veröffentlichungen Mizutani, Miyamoto, Nagahata, Konishi, Emi, Onda: "Upregulation and overexpression of DVL1, the human counterpart of the Drosophila dishevelled gene, in prostate cancer." in: Tumori, Vol. 91, Issue 6, pp. 546-51, 2006 (PubMed).