MMP 9 Antikörper (N-Term)

Produktnummer ABIN2777743

Produktdetails anti-MMP 9 Antikörper

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Kaninchen, Rind (Kuh), Hund, Pferd, Zebrafisch (Danio rerio), Meerschweinchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP 9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: VAEHGDGYPF DGKDGLLAHA FPPGPGIQGD AHFDDDELWS LGKGVVVPTR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MMP9. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MMP9

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 707 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MMP 9 Antikörper (ABIN2777743)

Puttabyatappa, Irwin, Martin, Mesquitta, Veiga-Lopez, Padmanabhan: "Developmental Programming: Gestational Exposure to Excess Testosterone Alters Expression of Ovarian Matrix Metalloproteases and Their Target Proteins" in: Reproductive sciences (Thousand Oaks, Calif.), pp. 1933719117697130, (2017) (PubMed).

Strilakou, Perelas, Lazaris, Papavdi, Karkalousos, Giannopoulou, Kriebardis, Panayiotides, Liapi: "Immunohistochemical determination of the extracellular matrix modulation in a rat model of choline-deprived myocardium: the effects of carnitine." in: Fundamental & clinical pharmacology, Vol. 30, Issue 1, pp. 47-57, (2016) (PubMed).

Zhang, Jiang, Zuo: "Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor κB." in: Neuroscience, Vol. 261, pp. 1-10, (2014) (PubMed).

Li, Tan, Zhang, Han, Di, Xiao, Cheng, Gao, Liu: "DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression depending on Notch signaling." in: PLoS ONE, Vol. 9, Issue 3, pp. e91509, (2014) (PubMed).

Deng, Zhang, Feng, Xiong, Zuo: "Critical role of matrix metalloprotease-9 in chronic high fat diet-induced cerebral vascular remodelling and increase of ischaemic brain injury in mice†." in: Cardiovascular research, Vol. 103, Issue 4, pp. 473-84, (2014) (PubMed).

Gotschy, Bauer, Schrodt, Lykowsky, Ye, Rommel, Jakob, Bauer, Herold: "Local arterial stiffening assessed by MRI precedes atherosclerotic plaque formation." in: Circulation. Cardiovascular imaging, Vol. 6, Issue 6, pp. 916-23, (2013) (PubMed).

Details zu MMP 9

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Andere Bezeichnung: MMP9 (MMP9 Produkte)

Synonyme: CLG4B antikoerper, GELB antikoerper, MANDP2 antikoerper, MMP-9 antikoerper, AW743869 antikoerper, B/MMP9 antikoerper, Clg4b antikoerper, pro-MMP-9 antikoerper, mmp-9 antikoerper, fgMMP-9 antikoerper, mmp9 antikoerper, ZFMMP-9 antikoerper, wu:fb02g06 antikoerper, wu:fb07b05 antikoerper, wu:fi98c09 antikoerper, wu:fj05a08 antikoerper, zgc:64165 antikoerper, clg4b antikoerper, gelb antikoerper, mandp2 antikoerper, matrix metallopeptidase 9 antikoerper, collagenase antikoerper, matrix metalloproteinase 9 antikoerper, matrix metallopeptidase 9 S homeolog antikoerper, MMP9 antikoerper, RB3913 antikoerper, BPSS0666 antikoerper, Sbal_3732 antikoerper, Bcer98_0486 antikoerper, Shew185_0630 antikoerper, Shal_3056 antikoerper, Sbal195_0657 antikoerper, Lbys_3550 antikoerper, Palpr_2084 antikoerper, Mmp9 antikoerper, mmp9 antikoerper, mmp9.S antikoerper

Hintergrund: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
Alias Symbols: GELB, CLG4B, MMP-9, MANDP2
Protein Interaction Partner: CXCL5, PZP, MMP26, RECK, KISS1, PRSS2, EPHB2, BTC, LCN2, COL4A6, COL4A5, TIMP3, THBS2, THBS1, MMP10, MMP7, PLG, CXCL1, TFPI, CXCL8, FN1, MMP9, COL1A2, COL1A1, COL4A4, COL4A1, COL4A2, COL4A3, HAPLN1, CD44, AREG, TGFB1, CXCL6,
Protein Size: 707

Molekulargewicht: 78 kDa

Gen-ID: 4318

NCBI Accession: NM_004994, NP_004985

UniProt: P14780

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events