ERCC8 Antikörper (C-Term)
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- Target Alle ERCC8 Antikörper anzeigen
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Ratte, Hund, Kaninchen, Pferd, Schwein
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ERCC8 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- QELYSGSRDC NILAWVPSLY EPVPDDDETT TKSQLNPAFE DAWSSSDEEG
- Homologie
- Dog: 93%, Horse: 86%, Human: 100%, Pig: 79%, Rabbit: 79%, Rat: 79%
- Produktmerkmale
- This is a rabbit polyclonal antibody against ERCC8. It was validated on Western Blot and immunohistochemistry.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human ERCC8
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 396 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines." in: Oncotarget, Vol. 8, Issue 25, pp. 40152-40168, (2018) (PubMed).
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Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines." in: Oncotarget, Vol. 8, Issue 25, pp. 40152-40168, (2018) (PubMed).
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- Target
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
- Andere Bezeichnung
- ERCC8 (ERCC8 Produkte)
- Synonyme
- zgc:103550 antikoerper, CKN1 antikoerper, CSA antikoerper, UVSS2 antikoerper, Ckn1 antikoerper, 2410022P04Rik antikoerper, 2810431L23Rik antikoerper, 4631412O06Rik antikoerper, B130065P18Rik antikoerper, Csa antikoerper, excision repair cross-complementation group 8 antikoerper, ERCC excision repair 8, CSA ubiquitin ligase complex subunit antikoerper, excision repaiross-complementing rodent repair deficiency, complementation group 8 antikoerper, ercc8 antikoerper, ERCC8 antikoerper, Ercc8 antikoerper
- Hintergrund
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ERCC8 (excision repair cross-complementing rodent repair deficiency, complementation group 8 isoform 1) is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcript
Alias Symbols: CKN1, CSA
Protein Interaction Partner: CUL4A, CUL4B, DDB1, RUVBL2, ZNF24, PCNA, H1F0, ERCC6, UVSSA, DDA1, RFWD2, COPS4, COPS6, COPS3, TOP1, TP53, SSBP1, OGG1, MDM2, GTF2H2, CUL5, GPS1, DDB2, COPS2, COPS7A, COPS5, COPS8, RBX1, POLR2A, HMGN1, EP300, UBC, CSNK2B, XAB2, UQCRQ, CBR1,
Protein Size: 396 - Molekulargewicht
- 44 kDa
- Gen-ID
- 1161
- NCBI Accession
- NM_000082, NP_000073
- UniProt
- Q13216
- Pathways
- DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus
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