FECH Antikörper (N-Term)

Produktnummer ABIN2776936

Produktdetails anti-FECH Antikörper

Target: FECH (Ferrochelatase (FECH))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FECH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LDRDLMTLPI QNKLAPFIAK RRTPKIQEQY RRIGGGSPIK IWTSKQGEGM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 77%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against FECH. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FECH

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 429 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FECH Antikörper (ABIN2776936)

Miyake, Ishii, Kawashima, Kodama, Sugano, Fujimoto, Hirao: "siRNA-mediated knockdown of the heme synthesis and degradation pathways: modulation of treatment effect of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines." in: Photochemistry and photobiology, Vol. 85, Issue 4, pp. 1020-7, (2009) (PubMed).

Details zu FECH

Target: FECH (Ferrochelatase (FECH))

Andere Bezeichnung: FECH (FECH Produkte)

Synonyme: AI894116 antikoerper, Fcl antikoerper, fch antikoerper, zgc:109851 antikoerper, EPP antikoerper, FCE antikoerper, CG2098 antikoerper, Dmel\\CG2098 antikoerper, GB15952 antikoerper, ferrochelatase L homeolog antikoerper, ferrochelatase antikoerper, Ferrochelatase antikoerper, ferrochelatase, mitochondrial antikoerper, ferrochelatase HemH antikoerper, ferrochelatase (predicted) antikoerper, fech.L antikoerper, hemH antikoerper, Fech antikoerper, FECH antikoerper, fech antikoerper, FeCH antikoerper, LOC409922 antikoerper, hem15 antikoerper, APH_RS01140 antikoerper

Hintergrund: Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria.Ferrochelatase is localized to the mitochondrion where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Defects in ferrochelatase are associated with protoporphyria. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: EPP, FCE
Protein Interaction Partner: PPP2R1A, UBC, NEDD8, MDM2, FBXO6, gag-pol, COPS5, COPS6, CUL3, ELAVL1, MINOS1, MME, USP42, USP20, ABCB7, FECH,
Protein Size: 429

Molekulargewicht: 47 kDa

Gen-ID: 2235

NCBI Accession: NM_001012515, NP_001012533

UniProt: Q8NAN0

Pathways: Transition Metal Ion Homeostasis