TNFRSF6B Antikörper

Produktnummer ABIN2664922

Produktdetails anti-TNFRSF6B Antikörper

Target: TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNFRSF6B Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: B08-35

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu TNFRSF6B

Target: TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))

Andere Bezeichnung: DcR3 (TNFRSF6B Produkte)

Synonyme: DCR3 antikoerper, DJ583P15.1.1 antikoerper, M68 antikoerper, M68E antikoerper, TR6 antikoerper, dcr3 antikoerper, m68 antikoerper, tr6 antikoerper, TNF receptor superfamily member 6b antikoerper, tumor necrosis factor receptor superfamily, member 11b antikoerper, regulator of telomere elongation helicase 1 antikoerper, TNF receptor superfamily member 6b L homeolog antikoerper, TNFRSF6B antikoerper, tnfrsf11b antikoerper, RTEL1 antikoerper, tnfrsf6b antikoerper, tnfrsf6b.L antikoerper

Hintergrund: The DcR3 protein is a soluble member of the TNF receptor superfamily containing four TNF receptor domains with an approximate molecular weight of 35 kD. DcR3, also known as Decoy receptor 3, TR6, M68, can be secreted by monocytes and myeloid-derived dendritic cells following exposure to bacterial antigens. DcR3 is overexpressed in tumors including lung and colon cancers, gliomas, and pancreatic cancers and can be detected in the serum of cancer patients. DcR3 can also be found in the cytoplasm and endoplasmic reticulum in some cell types. This protein competes for ligand binding with cell surface receptor and can inhibit their signaling. DcR3 has been shown to bind the ligands FasL, LIGHT, and TNF like molecule 1 (TL1A) to inhibit binding to the cell surface receptors Fas, HVEM and LT-ßR, and death receptor 3 (DR3), respectively.