KCNA2 antikoerper, kcna2 antikoerper, HBK5 antikoerper, HK4 antikoerper, HUKIV antikoerper, KV1.2 antikoerper, MK2 antikoerper, NGK1 antikoerper, RBK2 antikoerper, Akr6a4 antikoerper, ENSMUSG00000074335 antikoerper, Gm10672 antikoerper, Kca1-2 antikoerper, Kv1.2 antikoerper, Mk-2 antikoerper, BK2 antikoerper, XSha2 antikoerper, k(v)1.2 antikoerper, kcna2-a antikoerper, kv1.2 antikoerper, potassium voltage-gated channel subfamily A member 2 antikoerper, potassium channel, voltage gated shaker related subfamily A, member 1 antikoerper, potassium voltage-gated channel, shaker-related subfamily, member 2 antikoerper, potassium channel, voltage gated shaker related subfamily A, member 2 S homeolog antikoerper, KCNA2 antikoerper, kcna1 antikoerper, Kcna2 antikoerper, LOC100537815 antikoerper, kcna2.S antikoerper
Hintergrund
The Kv1.2 potassium channel is a voltage-gated channel protein which belongs to the delayed rectifier class and to the Shaker potassium channel subfamily which includes Kv1.1, Kv1.3, Kv1.4 and Kv1.5. Potassium channels are mainly found in plasma membranes but are not generally distributed over the cell surface. Potassium channels catalyze the rapid permeation of potassium ions while rejecting biologically abundant potential competitors such as sodium, calcium and magnesium. Ion selectivity and high through put rate of potassium channels is accomplished by precise co-ordination of dehydrated potassium by the protein and multiple ion occupancy within the permeation pathway. All potassium channels carry out the formation of a transmembrane leak specific for potassium ions. Since cells almost universally maintain cytoplasmic potassium concentrations higher than those extracellularly, the opening of a potassium channel implies a negative ongoing change in electrical voltage across the cell membrane. This may result in termination of the action potential of electrically excitable cells including nerve, muscle and pancreatic beta cells. In non-excitable cells, potassium channels play important roles in the cellular potassium recycling required for electrolyte balance effected by the renal epithelium.Synonyms: HBK5, HUKIV, KCNA2, NGK1, Potassium voltage-gated channel subfamily A member 2, Voltage-gated potassium channel subunit Kv1.2