Protocadherin gamma Subfamily C, 3 (PCDHGC3) Antikörper

Produktnummer ABIN2458926

Produktdetails

Target: Protocadherin gamma Subfamily C, 3 (PCDHGC3)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PCDHGC3.

Anwendungsinformationen

Applikationshinweise: PCDHGC3 antibody can be used for detection of PCDHGC3 by ELISA at 1:312500. PCDHGC3 antibody can be used for detection of PCDHGC3 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PCDHGC3 antibody at -20 °C.

Antigendetails

Target: Protocadherin gamma Subfamily C, 3 (PCDHGC3)

Andere Bezeichnung: PCDHGC3 (PCDHGC3 Produkte)

Synonyme: PC43 antikoerper, PCDH-GAMMA-C3 antikoerper, PCDH2 antikoerper, Pcdh2 antikoerper, PCDHGA11 antikoerper, PCDHGC5 antikoerper, protocadherin gamma subfamily C, 3 antikoerper, PCDHGC3 antikoerper, Pcdhgc3 antikoerper

Hintergrund: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. PCDHGC3 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Molekulargewicht: 98 kDa

Gen-ID: 5098

NCBI Accession: NP_002579

UniProt: Q9UN70