Endoglin Antikörper
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- Target Alle Endoglin (ENG) Antikörper anzeigen
- Endoglin (ENG)
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Reaktivität
- Maus
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Wirt
- Ratte
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Klonalität
- Monoklonal
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Konjugat
- Dieser Endoglin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Spezifität
- The rat monoclonal antibody MJ7/18 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow.
- Kreuzreaktivität (Details)
- Mouse
- Aufreinigung
- Purified by protein-G affinity chromatography.
- Reinheit
- > 95 % (by SDS-PAGE)
- Immunogen
- Inflamed mouse skin
- Klon
- MJ7-18
- Isotyp
- IgG2a kappa
- Top Product
- Discover our top product ENG Primärantikörper
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- Applikationshinweise
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Do not freeze. Do not use after expiration date stamped on vial label.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Do not freeze.
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Current limitations of molecular magnetic resonance imaging for tumors as evaluated with high-relaxivity CD105-specific iron oxide nanoparticles." in: Investigative radiology, Vol. 47, Issue 7, pp. 383-91, (2012) (PubMed).
: "Identification of a candidate proteomic signature to discriminate multipotent and non-multipotent stromal cells." in: PLoS ONE, Vol. 7, Issue 6, pp. e38954, (2012) (PubMed).
: "Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours." in: Cardiovascular research, Vol. 86, Issue 1, pp. 12-9, (2010) (PubMed).
: "Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells." in: Anticancer research, Vol. 25, Issue 3B, pp. 1851-64, (2005) (PubMed).
: "Contact sensitizers specifically increase MHC class II expression on murine immature dendritic cells." in: In vitro & molecular toxicology, Vol. 13, Issue 2, pp. 113-23, (2001) (PubMed).
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Current limitations of molecular magnetic resonance imaging for tumors as evaluated with high-relaxivity CD105-specific iron oxide nanoparticles." in: Investigative radiology, Vol. 47, Issue 7, pp. 383-91, (2012) (PubMed).
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- Target
- Endoglin (ENG)
- Andere Bezeichnung
- CD105 (ENG Produkte)
- Synonyme
- ENG antikoerper, MGC137842 antikoerper, DKFZp469D0419 antikoerper, END antikoerper, HHT1 antikoerper, ORW1 antikoerper, AI528660 antikoerper, AI662476 antikoerper, CD105 antikoerper, S-endoglin antikoerper, endoglin antikoerper, ENG antikoerper, Eng antikoerper
- Hintergrund
- Endoglin,CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.,Endoglin, END, ENG
- Gen-ID
- 13805
- UniProt
- Q63961
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