Endoglin Antikörper (APC)

Produktnummer ABIN192217

Produktdetails anti-Endoglin Antikörper (APC)

Target: Endoglin (ENG)

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Endoglin Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Spezifität: The antibody MEM-226 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.

Kreuzreaktivität (Details): Human, Rat

Aufreinigung: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Recombinant Vaccinia virus containing the human CD105 cDNA.

Klon: MEM-226

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Kommentare:

The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: No reconstitution is necessary.

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.
Avoid prolonged exposure to light.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-Endoglin Antikörper (APC) (ABIN192217)

Schmidt, Achermann, Odermatt, Breymann, Mol, Genoni, Zund, Hoerstrup: "Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source." in: Circulation, Vol. 116, Issue 11 Suppl, pp. I64-70, (2007) (PubMed).

Details zu Endoglin

Target: Endoglin (ENG)

Andere Bezeichnung: CD105 (ENG Produkte)

Synonyme: ENG antikoerper, MGC137842 antikoerper, DKFZp469D0419 antikoerper, END antikoerper, HHT1 antikoerper, ORW1 antikoerper, AI528660 antikoerper, AI662476 antikoerper, CD105 antikoerper, S-endoglin antikoerper, endoglin antikoerper, ENG antikoerper, Eng antikoerper

Hintergrund: Endoglin,CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.,Endoglin, END, ENG, HHT1, ORW1

Gen-ID: 2022

UniProt: P17813