TOLLIP Antikörper (C-Term)

Produktnummer ABIN1882142

Produktdetails anti-TOLLIP Antikörper

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Bindungsspezifität: AA 221-250, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TOLLIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This TOLLIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-250 amino acids from the C-terminal region of human TOLLIP.

Klon: RB4409

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-TOLLIP Antikörper (ABIN1882142)

Chen, Choong, Lin, Philp, Wong, Ang, Tan, Loh, Hew, Shah, Druker, Chong, Lim: "Differential expression of novel tyrosine kinase substrates during breast cancer development." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 12, pp. 2072-87, (2007) (PubMed).

Zhang, Ghosh: "Negative regulation of toll-like receptor-mediated signaling by Tollip." in: The Journal of biological chemistry, Vol. 277, Issue 9, pp. 7059-65, (2002) (PubMed).

Bulut, Faure, Thomas, Equils, Arditi et al.: "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 2, pp. 987-94, (2001) (PubMed).

Burns, Clatworthy, Martin, Martinon, Plumpton, Maschera, Lewis, Ray, Tschopp, Volpe: "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor." in: Nature cell biology, Vol. 2, Issue 6, pp. 346-51, (2000) (PubMed).

Volpe, Clatworthy, Kaptein, Maschera, Griffin, Ray: "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex." in: FEBS letters, Vol. 419, Issue 1, pp. 41-4, (1998) (PubMed).

Details zu TOLLIP

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Andere Bezeichnung: TOLLIP (TOLLIP Produkte)

Synonyme: IL-1RAcPIP antikoerper, 4930403G24Rik antikoerper, 4931428G15Rik antikoerper, fk22a02 antikoerper, im:7145391 antikoerper, wu:fk22a02 antikoerper, zgc:76985 antikoerper, TOLLIP antikoerper, GB17961 antikoerper, tollip antikoerper, tollip1 antikoerper, tollipa antikoerper, TOLIP antikoerper, toll interacting protein antikoerper, toll-interacting protein antikoerper, toll-interacting protein-like antikoerper, toll interacting protein L homeolog antikoerper, toll interacting protein S homeolog antikoerper, Toll-interleukine I receptor interacting protein I antikoerper, TOLLIP antikoerper, Tollip antikoerper, tollip antikoerper, LOC552034 antikoerper, LOC100169858 antikoerper, tollip.L antikoerper, tollip.S antikoerper, LOC100136122 antikoerper

Hintergrund: Toll like protein is a component of the signaling pathway of IL1 and Toll like receptors. It inhibits cell activation by microbial products. Tollip recruits IRAK1 to the IL1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity. It oligomerizes and binds to TLR2 and the TLR4-MD2 complex via its C terminus. It exists as a complex with IRAK1 in unstimulated cells. Upon IL1 signaling, Tollip binds to the activated IL1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. TOLLIP also interacts with TLR2 and TLR4, TOLLIP overexpression inhibits nuclear factor kappa-B (NFKB) activation in response to lipopolysaccharide and IL1B.

Molekulargewicht: 30282

NCBI Accession: NP_061882

UniProt: Q9H0E2