CCNDBP1 Antikörper (N-Term)

Produktnummer ABIN1881181

Produktdetails anti-CCNDBP1 Antikörper

Target: CCNDBP1 (Cyclin D-Type Binding-Protein 1 (CCNDBP1))

Bindungsspezifität: AA 21-49, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCNDBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Pr

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CCNDBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of human CCNDBP1.

Klon: RB40537

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-CCNDBP1 Antikörper (ABIN1881181)

Lee, Yeom, Lee, Kang, Park: "A novel senescence-evasion mechanism involving Grap2 and Cyclin D interacting protein inactivation by Ras associated with diabetes in cancer cells under doxorubicin treatment." in: Cancer research, Vol. 70, Issue 11, pp. 4357-65, (2010) (PubMed).

Seto, Ikushima, Suzuki, Sato, Fukai, Yuki, Miyazawa, Miyazono, Ishitani, Nureki: "Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 65, Issue Pt 1, pp. 21-4, (2009) (PubMed).

Ikushima, Komuro, Isogaya, Shinozaki, Hellman, Miyazawa, Miyazono: "An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling." in: The EMBO journal, Vol. 27, Issue 22, pp. 2955-65, (2008) (PubMed).

Chen, Su, Jin, Chang, Chang: "Immunohistochemical expression of GCIP in breast carcinoma: relationship with tumour grade, disease-free survival, mucinous differentiation and response to chemotherapy." in: Histopathology, Vol. 53, Issue 5, pp. 554-60, (2008) (PubMed).

Chang, Chen, Chen, Su, Chang, Chang: "Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells." in: Oncogene, Vol. 27, Issue 3, pp. 332-8, (2008) (PubMed).

Details zu CCNDBP1

Target: CCNDBP1 (Cyclin D-Type Binding-Protein 1 (CCNDBP1))

Andere Bezeichnung: CCNDBP1 (CCNDBP1 Produkte)

Synonyme: CCNDBP1 antikoerper, dip1 antikoerper, gcip antikoerper, DIP1 antikoerper, GCIP antikoerper, HHM antikoerper, AU022347 antikoerper, Maid antikoerper, SECC-8 antikoerper, SSEC-8 antikoerper, cyclin D1 binding protein 1 antikoerper, cyclin D-type binding-protein 1 antikoerper, CCNDBP1 antikoerper, ccndbp1 antikoerper, Ccndbp1 antikoerper

Hintergrund: This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq].

Molekulargewicht: 40262

NCBI Accession: NP_036274

UniProt: O95273