pADPR Antikörper (Agarose Beads)

Produktnummer ABIN1741705

Produktdetails

Target: pADPR

Reaktivität: Alle Spezies

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Agarose Beads

Applikation: Immunoprecipitation (IP)

Produktmerkmale: Recognizes DNA-damage and apoptosis related poly-ADP ribosylated proteins and poly (ADP-ribose) polymer

Aufreinigung: Protein A affinity column

Immunogen: poly(ADP-ribose)

Klon: 10H

Isotyp: IgG3

Anwendungsinformationen

Applikationshinweise: 0.5 µg/IP reaction

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, pH 7.4 with 0,05 % sodium azides

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C

Informationen zur Lagerung: Stable for 1 year from date of shipment when stored at -20 °C or -70 °C. Stable for at least 1 month at 4 °C.

Referenzen

Kanai, Tong, Sugihara, Wang, Fukasawa, Miwa: "Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function." in: Molecular and cellular biology, Vol. 23, Issue 7, pp. 2451-62, (2003) (PubMed).

Antigendetails

Target: pADPR

Hintergrund: Synonyms: poly(ADP-ribose)
Poly(ADP-ribose) or pADPr is a polymer synthesized by a class of enzymes named poly(ADP-ribose) polymerase (PARP). Using NAD+ as substrate, PARP catalyzes the formation of the polymer pADPr, with chain lengths ranging from 2 to 300 residues, containing approximately 2 % branching in the chain. pADPr becomes attached to nuclear proteins, and to PARP itself (automodification).