Suitable for use in Western blot (0.5 to 2 μg/mL). Human kidney or human testis cell lysatecan be used as positive control and a 90 kDa band can be detected. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
0.5mg/mL
Buffer
PBS containing 0.02 % Sodium azide as preservative.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
ACE1 antikoerper, CD143 antikoerper, DCP antikoerper, DCP1 antikoerper, ICH antikoerper, MVCD3 antikoerper, ACEH antikoerper, 2010305L05Rik antikoerper, zgc:92514 antikoerper, angiotensin I converting enzyme antikoerper, angiotensin I converting enzyme 2 antikoerper, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 antikoerper, ACE antikoerper, ACE2 antikoerper, Ace2 antikoerper, ace2 antikoerper
Hintergrund
Angiotensin converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1 7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE1 inhibitors such as catopril and lisinopril do not block ACE2 activity. The full length sequence for ACE2 encodes an 805 amino acid protein with predicted mass of 92.46 kDa and a pI of 5.22.Synonyms: ACE-related carboxypeptidase, Angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog