Dieser Myeloperoxidase Antikörper ist unkonjugiert
Applikation
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody detects Myeloperoxidase at C-term. No cross reactivity with other proteins.
Kreuzreaktivität (Details)
Species reactivity (tested):Human, Mouse, Rat.
Aufreinigung
Immunogen Affinity Chromatography
Immunogen
Synthetic peptide corresponding to a sequence mapping at the C-terminal of human MPO .Remarks: Sequence is identical to the related mouse and rat sequence
This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Chang, Tseng, Lee, Hwang, Chen, Su, Chong, Lan, Wu, Chen, Lu, Liao, Hsueh, Hsieh: "β-Nitrostyrene derivatives attenuate LPS-mediated acute lung injury via the inhibition of neutrophil-platelet interactions and NET release." in: American journal of physiology. Lung cellular and molecular physiology, (2017) (PubMed).
Myeloperoxidase (MPO) is a mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions. It is abundantly expressed in neutrophils and secreted during their activation. Myeloperoxidase is part of the host defense system of human polymorphonuclear leukocytes, responsible for microbicidal activity against a wide range of organisms. It is located in the nucleus as well as in the cytoplasm. Intranuclear MPO may help to protect DNA against damage resulting from oxygen radicals produced during myeloid cell maturation and function.Synonyms: MPO