C5 Antikörper

Produktnummer ABIN1106792

Produktdetails anti-C5 Antikörper

Target: C5 (Complement Component 5 (C5))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Functional Studies (Func)

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G

Klon: 2942

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu C5

Target: C5 (Complement Component 5 (C5))

Andere Bezeichnung: Complement C5 (C5 Produkte)

Synonyme: C5 antikoerper, LOC565774 antikoerper, C5a antikoerper, C5b antikoerper, CPAMD4 antikoerper, Hc antikoerper, RGD1561905 antikoerper, He antikoerper, complement C5 antikoerper, complement component 5 antikoerper, hemolytic complement antikoerper, C5 antikoerper, c5 antikoerper, Hc antikoerper

Hintergrund: C5a is a single chain glycopeptide composed of 74-amino-acids, which is rapidly converted to the less potent derivate C5a des-Arg upon removal of the C-terminal arginine by carboxypeptidase B. C5a acts as a potent anaphylatoxin by binding to its high affinity receptor C5aR (or CD88) on the membrane of target cells inducing smooth muscle contraction, increased vascular permeability, degranulation of mast cells and basophils, and the release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. C5a is involved in inflammatory reactions seen in gram-negative bacterial sepsis, trauma, ischemic heart disease, post-dialysis syndrome and a variety of autoimmune diseases. Elevation of C5a is associated with increased cardiovascular risk in patients with advanced atherosclerosis. Also, C5a is closely associated with the capillary leak syndrome in leukemic children after bone marrow transplantation. C5a is also a marker in urine for predicting the onset of acute graft rejection after kidney transplantation and has been shown to be present in extracellular deposits in patients suffering from age-related macular degeneration (AMD).Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, CPAMD4, Complement component 5

Gen-ID: 9606

UniProt: P01031

Pathways: Komplementsystem, Carbohydrate Homeostasis