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Atg38 and its human ortholog NRBF2 (zeige NRBF2 ELISA Kits), accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6 (zeige BECN1 ELISA Kits)-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1 (zeige BECN1 ELISA Kits)-ATG14 (human), were characterized.
p300 (zeige EP300 ELISA Kits)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Low VPS34 expression is associated with cancer.
Arf tumor suppressor as a new transcriptional target of nuclear EGFR and highlight Vps34 as an important regulator of the nuclear EGFR/Arf survival pathway.
Vps34 has a previously unknown role in regulating Rab7 (zeige RAB7B ELISA Kits) activity and late endosomal trafficking.
High expression of VPS34 promoted GRP78 (zeige HSPA5 ELISA Kits) transcription by modulating ATF6 (zeige ATF6 ELISA Kits). VPS34 could enhance GRP78 (zeige HSPA5 ELISA Kits) protein stability.
These results establish Vps34 as an essential determinant of both short-term and long-term canonical GPCR signaling.
Study identifies a key role of Cul3 (zeige CUL3 ELISA Kits)-KLHL20 (zeige KLHL20 ELISA Kits) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (zeige ULK1 ELISA Kits) and VPS34 complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.
cis (zeige CISH ELISA Kits)-unsaturated fatty acids require neither BECN1 (zeige BECN1 ELISA Kits) nor PIK3C3 to stimulate the autophagic flux
tubulation requires mTOR (zeige FRAP1 ELISA Kits) activity, and we identified two direct mTOR (zeige FRAP1 ELISA Kits) phosphorylation sites on UVRAG (S550 and S571) that activate VPS34.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
confirmed that the polymorphism in PIK3C3 (C2604T) has the potential to be a genetic marker for production traits in Duroc pigs
This study uncovers a dual role for Vps34 as a regulator of platelet production by megakaryocytes and as an unexpected regulator of platelet activation and arterial thrombus formation dynamics.
E. chaffeensis secretes Etf-1 (zeige ETF1 ELISA Kits) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 (zeige RAB5A ELISA Kits) and class III PtdIns3K, while avoiding autolysosomal killing.
p300 (zeige NOTCH1 ELISA Kits)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Vps34 has a previously unknown role in regulating Rab7 (zeige RAB7A ELISA Kits) activity and late endosomal trafficking.
PIK3C3 was strongly expressed in the axon of cortical neurons during brain development.
provide the novel evidence that GADD45A (zeige GADD45A ELISA Kits) inhibits autophagy via impairing the BECN1 (zeige BECN1 ELISA Kits)-PIK3C3 complex formation
PAQR3 controls autophagy by integrating AMPK (zeige PRKAA1 ELISA Kits) signaling to enhance ATG14L-associated PI3K activity
Depletion of hepatic Vps15, the regulatory subunit of class III PI3K, increases insulin (zeige INS ELISA Kits) sensitivity and Akt (zeige AKT1 ELISA Kits) signaling.
Beclin 1 (zeige BECN1 ELISA Kits) regulates endosome pathways via the UVRAG-VPS34 complex.
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis (By similarity).
phosphoinositide-3-kinase, class 3
, phosphatidylinositol 3-kinase catalytic subunit type 3
, PI3K type 3
, PI3-kinase type 3
, ptdIns-3-kinase type 3
, phosphoinositide-3-kinase class 3
, catalytic phosphatidylinositol 3-kinase 3
, PtdIns-3-kinase type 3
, phosphatidylinositol 3-kinase p100 subunit
, class 3 phosphoinositide-3-kinase
, PI-3K Vps34p