3-Hydroxy-3-Methylglutaryl-CoA Reductase ELISA Kits (HMGCR)
Auf finden Sie aktuell 29 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) ELISA Kits von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HMGCR Antikörper (86) und HMGCR Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 125 HMGCR Produkte verfügbar.
3H3M, BcDNA:LD15354, bro1, bs32f05.y1, CG10367, clb, Dmel\\CG10367, DmHMG-CoAr, Hmg, hmg-coa-r, HMG-CoAR, hmgc, HMGCoAr, HMGCoARr, hmgcr, HMGCR_Dm, HMGR, hmgrc, l(3)01152, l(3)04684, LDLCQ3, Red

Am meisten referenzierte HMGCR ELISA Kits

  1. Rat (Rattus) HMGCR ELISA Kit für Sandwich ELISA - ABIN433888 : Zhang, Yu, Ma, Liu, Han, Wang, Xiao: 27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain. in Neuroscience 2015 (PubMed)
    Zeige alle 2 Referenzen für 433888

Weitere ELISA Kits für HMGCR Interaktionspartner

Fruit Fly (Drosophila melanogaster) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Interaktionspartner

  1. The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos.

Human 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Interaktionspartner

  1. To estimate the association between changes in levels of LDL-C (and other lipoproteins) and the risk of cardiovascular events related to variants in the CETP (zeige CETP ELISA Kits) gene, both alone and in combination with variants in the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) gene.

  2. Low LDL cholesterol levels due to PCSK9 (zeige PCSK9 ELISA Kits) and HMGCR variants had no causal effect on high risk of Alzheimer's disease, vascular dementia, any dementia, or Parkinson's disease; however, low LDL cholesterol levels may have a causal effect in reducing the risk of Alzheimer's disease.

  3. These results indicate that HIF-mediated induction of Insig-2 (zeige INSIG2 ELISA Kits) and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  4. TGF-beta1 (zeige TGFB1 ELISA Kits) induces cholesterol synthesis by increasing HMG-CoA reductase mRNA expression in keratinocytes.

  5. Gene expression profile and the biological functions of HMGCR in gastric cancer were studied. It was found that the expression of HMGCR was increased in gastric cancer tissues. Over-expression of HMGCR promoted the growth and migration of gastric cancer cells, while knocking down the expression of HMGCR inhibited the growth, migration and tumorigenesis of gastric cancer cells.

  6. In this study, variants in PCSK9 (zeige PCSK9 ELISA Kits) had approximately the same effect as variants in HMGCR on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive.

  7. Data show that simvastatin significantly inhibited cellular proliferation, induced cell cycle G1 arrest and apoptosis, and caused cellular stress via reduction in the enzymatic activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR).

  8. no associations found between HMGCR rs3846662, HMRCR alternative splicing and Alzheimer's disease pathology pathology.

  9. results indicate that abnormal lipid metabolism may exist in spontaneous preterm delivery (SPTD) women and the premature fetus and the HMGCR gene may be a susceptible gene for SPTD

  10. Report the mechanism of polyphenol binding to and activity regulation of HMGR (zeige HMGA1 ELISA Kits) using molecular docking.

Pig (Porcine) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Interaktionspartner

  1. The relative expression level of HMGR was high in liver, heart, kidney, bladder and subcutaneous fat, medium in lung, uterus and large intestine, and low in cerebrum, spleen, spinal cord, stomach, ovary, longissimus muscle, and small intestine.

Mouse (Murine) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Interaktionspartner

  1. These results indicate that HIF-mediated induction of Insig-2 (zeige INSIG2 ELISA Kits) and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  2. these studies designate sterol-accelerated degradation of HMGCR as a potential therapeutic target for prevention of atherosclerosis and associated cardiovascular disease.

  3. To eludicate the mechanisms underlying statin myotoxicity and HMGCR function in skeletal muscle, we developed the skeletal muscle-specific (zeige EIF3K ELISA Kits) HMGCR knockout mice.

  4. High-dose simvastatin inhibits HMGCoA reductase and prevents experimental hyperinflation lung injury by angioprotective and anti-inflammatory effects.

  5. TSH can regulate the phosphorylation of HMGCR via AMPK (zeige PRKAA1 ELISA Kits).

  6. HMGCR proteasomal-degradation by IFN strictly requires the synthesis of endogenous 25-Hydroxycholesterol.

  7. Increased cholesterol synthesis mediated by HMGCoA (zeige HMGCS2 ELISA Kits)-R under inflammatory stress may be one of the mechanisms for intracellular lipid accumulation and statin resistance.

  8. we consistently observe involvement of gp78 (zeige AMFR ELISA Kits) in Insig-1 (zeige INSIG1 ELISA Kits) degradation, we find no substantive evidence to support roles for either gp78 (zeige AMFR ELISA Kits) or TRC8 (zeige RNF139 ELISA Kits) in the robust sterol-accelerated degradation of HMG-CoA reductase.

  9. Hepatocyte HMGCR is essential for the survival of mice, and its abrogation elicits hepatic steatosis with jaundice and hypoglycemia.

  10. Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms.

HMGCR Antigen-Profil

Beschreibung des Gens

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HMGCR

  • HMG Coenzyme A reductase (Hmgcr) Elisa Kit
  • 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) Elisa Kit
  • 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr) Elisa Kit
  • 3-hydroxy-3-methylglutaryl-CoA reductase (hmgcr) Elisa Kit
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr) Elisa Kit
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (LOC100357791) Elisa Kit
  • 3H3M Elisa Kit
  • BcDNA:LD15354 Elisa Kit
  • bro1 Elisa Kit
  • bs32f05.y1 Elisa Kit
  • CG10367 Elisa Kit
  • clb Elisa Kit
  • Dmel\\CG10367 Elisa Kit
  • DmHMG-CoAr Elisa Kit
  • Hmg Elisa Kit
  • hmg-coa-r Elisa Kit
  • HMG-CoAR Elisa Kit
  • hmgc Elisa Kit
  • HMGCoAr Elisa Kit
  • HMGCoARr Elisa Kit
  • hmgcr Elisa Kit
  • HMGCR_Dm Elisa Kit
  • HMGR Elisa Kit
  • hmgrc Elisa Kit
  • l(3)01152 Elisa Kit
  • l(3)04684 Elisa Kit
  • LDLCQ3 Elisa Kit
  • Red Elisa Kit

Bezeichner auf Proteinebene für HMGCR

3-Hydroxy-3-Methylglutaryl CoA reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase , CG10367-PA , HMG coenzyme A reductase , HMG-CoA reductase , HMGCo-A reductase , HMGCoA reductase , Hmg-CoA-reductase , Hmgcr-PA , columbus , lethal (3) 04684 , 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) , 3-hydroxy-3-methylglutaryl-Coenzyme A reductase , hydroxymethylglutaryl-CoA reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase/HMG-CoA reductase , 3-hydroxy-3-methylglutaryl-coenzyme A reductase , 3-hydroxy-3-methylglutaryl CoA reductase , 3-hydroxy-3-methylglutaryl-CoA reductase

42803 Drosophila melanogaster
3156 Homo sapiens
479182 Canis lupus familiaris
100144446 Sus scrofa
407159 Bos taurus
25675 Rattus norvegicus
395145 Gallus gallus
397750 Xenopus laevis
100173499 Pongo abelii
15357 Mus musculus
100357791 Oryctolagus cuniculus
100756363 Cricetulus griseus
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