anti-Human NLRC4 Antikörper für Flow Cytometry

Recommended NLRC4 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
NLR Family, CARD Domain Containing 4 (NLRC4) Antikörper
  • CARD12
  • CLAN
  • CLAN1
  • CLANA
  • CLANB
  • CLANC
  • CLAND
  • CLR2.1
  • IPAF
  • 9530011P19Rik
  • Card12
  • NLR family, CARD domain containing 4
  • NLRC4
  • Nlrc4
Reaktivität
Human
97
41
9
2
1
Wirt
Maus
90
7
Klonalität
Monoklonal
Konjugat
Dieser NLRC4 Antikörper ist unkonjugiert
4
3
2
2
2
2
2
2
2
2
2
2
2
2
Applikation
Flow Cytometry (FACS)
68
47
36
35
31
30
8
4
3
2
1
1
Hersteller
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Bilder

Produktnummer ABIN2665296
Preis und Verfügbarkeit auf Anfrage.
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1 ABIN5611209 ELISA FACS ICC IHC WB Mouse IgG1 AA 525-538 Anmelden zum Anzeigen 4B7B7

General

Antigen NLR Family, CARD Domain Containing 4 (NLRC4) Antikörper
Reaktivität Human
(97), (41), (9), (2), (1)
Wirt Maus
(90), (7)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser NLRC4 Antikörper ist unkonjugiert
(4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Applikation Flow Cytometry (FACS)
(68), (47), (36), (35), (31), (30), (8), (4), (3), (2), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-NLRC4 Antikörper

Target Details NLRC4 Anwendungsinformationen Handhabung Referenzen für anti-NLRC4 Antikörper (ABIN2665296) Bilder
Reinigung The antibody was purified by affinity chromatography.
Klon 6H9B13
Isotyp IgG2a kappa

Target Details NLRC4

Produktdetails anti-NLRC4 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-NLRC4 Antikörper (ABIN2665296) Bilder zurück nach oben
Antigen
Andere Bezeichnung NLRC4 (NLRC4 Antibody Abstract)
Hintergrund NLRC4 , also known as IPAF, is a member of the NOD-like receptor (NLR) family. The NLR proteins share a conserved DNA-binding NACHT domain, a caspase recruitment domain (CARD), and a leucine-rich repeat (LRR) domain responsible for pathogen pattern recognition. NLRC4 was found to play an important role in the innate immune response against bacterial infection. During Gram-negative bacteria infections, such as Shigella, Salmonella, Legionella, or Pseudomonas, NLRC4 detects and is activated by translocated bacterial flagellin or PrgJ-like rod proteins subsequently resulting in the assembly of the NLRC4 inflammasome. The activated inflammasome drives proteolytic activation of caspase-1, leading to the processing and secretion of the proinflamatory cytokines IL-1β and IL-18.
Pathways Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity

Anwendungsinformationen

Produktdetails anti-NLRC4 Antikörper Target Details NLRC4 Handhabung Referenzen für anti-NLRC4 Antikörper (ABIN2665296) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-NLRC4 Antikörper Target Details NLRC4 Anwendungsinformationen Referenzen für anti-NLRC4 Antikörper (ABIN2665296) Bilder zurück nach oben
Konzentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C.

Referenzen für anti-NLRC4 Antikörper (ABIN2665296)

Produktdetails anti-NLRC4 Antikörper Target Details NLRC4 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Cai, Batra, Wakamatsu, Pacher, Jeyaseelan: "NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 11, pp. 5623-35, 2012

Carvalho, Nalbantoglu, Aitken, Uchiyama, Su, Doho, Vijay-Kumar, Gewirtz: "Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges." in: Mucosal immunology, Vol. 5, Issue 3, pp. 288-98, 2012

Franchi, Kamada, Nakamura, Burberry, Kuffa, Suzuki, Shaw, Kim, Núñez: "NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense." in: Nature immunology, Vol. 13, Issue 5, pp. 449-56, 2012

Sauer, Pereyre, Archer, Burke, Hanson, Lauer, Portnoy: "Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 30, pp. 12419-24, 2011

Tomalka, Ganesan, Azodi, Patel, Majmudar, Hall, Fitzgerald, Hise: "A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans." in: PLoS pathogens, Vol. 7, Issue 12, pp. e1002379, 2011

Bilder

Produktdetails anti-NLRC4 Antikörper Target Details NLRC4 Anwendungsinformationen Handhabung Referenzen für anti-NLRC4 Antikörper (ABIN2665296) zurück nach oben
Bilder des Herstellers
Immunofluorescence (IF) image for anti-NLR Family, CARD Domain Containing 4 (NLRC4) antibody (ABIN2665296) anti-NLR Family, CARD Domain Containing 4 (NLRC4) antibody
Western Blotting (WB) image for anti-NLR Family, CARD Domain Containing 4 (NLRC4) antibody (ABIN2665296) anti-NLR Family, CARD Domain Containing 4 (NLRC4) antibody (Image 2)