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UMOD encodes uromodulin, the most abundant protein in normal urine. Zusätzlich bieten wir Ihnen Uromodulin Antikörper (184) und Uromodulin Kits (62) und viele weitere Produktgruppen zu diesem Protein an.
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Data show that one SNP (rs183962941), located in a non-coding region of uromodulin protein (UMOD), was nominally associated with end-stage renal disease (ESRD).
THP appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.
High urinary uromodulin levels are associated with lower risk for UTI (zeige AMBP Proteine) in older community-dwelling adults independent of traditional UTI (zeige AMBP Proteine) risk factors.
The uromodulin-CFH (zeige CFH Proteine) interaction enhanced the cofactor activity of CFH (zeige CFH Proteine) for factor I-mediated cleavage of C3b to inactivated C3b.
These findings suggest that the levels of urinary microvesicle-bound uromodulin are associated with the severity of diabetic kidney disease.
Data strongly suggest that the uromodulin ancestral allele, driving higher urinary excretion of uromodulin, has been kept at a high frequency because of its protective effect against urinary tract infections
The frequency of uromodulin single nucleotide polymorphism rs13333226 GG/GA genotype was significantly higher and the frequency of G allele was much higher in the patients with end stage renal disease than in the controls.
Serum uromodulin concentrations are closely correlated with estimated glomerular filtration rate, which is the recommended measure of renal function. As uromodulin is produced exclusively by renal tubular cells, the assessment of uromodulin levels in patients with chronic kidney disease may be an alternative method for evaluating the number of functioning nephrons.
novel UMOD missense mutation c.457T>G, p.(Cys153Gly) in patients with chronic kidney disease; mutation leads to severely reduced serum uromodulin concentrations
UMOD rs13333226 does not appear to be associated with preeclampsia in Han Chinese women.
Consistently, pathway enrichment analysis indicates that mutant uromodulin expression affects ER function and protein homeostasis.
we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 (zeige IL17A Proteine) axis and systemic neutrophilia.
TNFalpha (zeige TNF Proteine) regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha (zeige TNF Proteine) on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta (zeige HNF1B Proteine)-mediated expression of uromodulin.
AGP was more effective in limiting hepatic inflammation and maintaining perfusion than saline or HAS, in both endotoxemic and septic mice. AGP sequestration of LPS (zeige TLR4 Proteine) may contribute to its anti-inflammatory effects.
UMOD upregulates TRPV5 (zeige TRPV5 Proteine) by decreasing caveolin-1 (zeige CAV1 Proteine) dependent endocytosis of TRPV5 (zeige TRPV5 Proteine).
UMOD regulates sodium uptake in the thick ascending limb of the loop of Henle by modulating the effect of tumor necrosis factor-alpha (zeige TNF Proteine) on NKCC2A expression, making UMOD an important determinant of blood pressure control.
Genetic susceptibility link to hypertension and chronic kidney disease to uromodulin expression and uromodulin's effect on salt reabsorption in the kidney.
Using an ischemia-reperfusion model of murine acute kidney injury, we show that, while THP expression in thick ascending loop is downregulated at the peak of injury, it is significantly upregulated 48 h after.
Quercetin has the uricosuric and nephroprotective actions mediated by regulating the expression levels of renal organic ion transporters and UMOD.
a unifying model that underscores the role of THP as a major regulator of renal and systemic immunity.
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
, Tamm-Horsfall urinary glycoprotein
, tamm-Horsfall urinary glycoprotein
, uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
, Urmodulin (Tamm-Horsfall protein)
, uromucoid, human : Tamm-Horsfall glycoprotein