anti-Two Pore Segment Channel 2 (TPCN2) Antikörper

TPCN2 encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. Zusätzlich bieten wir Ihnen TPCN2 Proteine (5) und TPCN2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TPCN2 309139  
TPCN2 219931 Q8NHX9
TPCN2 233979 Q8BWC0
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Top anti-TPCN2 Antikörper auf antikoerper-online.de

Showing 10 out of 40 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Ziege Unkonjugiert IHC (p) Colon, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Human Ziege Unkonjugiert ELISA   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$317.63
Details
Human Ziege Unkonjugiert IHC (p) Colon, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$500.50
Details
Maus Kaninchen Unkonjugiert IHC, WB   100 μL Anmelden zum Anzeigen 7 bis 8 Tage
$454.67
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Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry-Paraffin: Two pore calcium channel protein 2 Antibody  - Staining of human kidney shows strong membranous positivity in cells in glomeruli and subset of cells in tubules. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$439.69
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Human Ziege Unkonjugiert ELISA, WB   0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
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Human Kaninchen Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$405.17
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Human Kaninchen Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$405.17
Details
Human Kaninchen Unkonjugiert IHC, WB   100 μL Anmelden zum Anzeigen 7 bis 8 Tage
$454.67
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Human Kaninchen Unkonjugiert IHC, ELISA, WB   100 μg Anmelden zum Anzeigen 3 bis 4 Tage
$157.06
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TPCN2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Rat (Rattus)


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Human , , ,
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Mouse (Murine)


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Am meisten referenzierte anti-TPCN2 Antikörper

  1. Human Polyclonal TPCN2 Primary Antibody für IHC, ELISA - ABIN2687105 : Lee, Tong, Cheng, Hung, Cheung: Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology. in Scientific reports 2016 (PubMed)

  2. Human Polyclonal TPCN2 Primary Antibody für ELISA - ABIN4250202 : Calcraft, Ruas, Pan, Cheng, Arredouani, Hao, Tang, Rietdorf, Teboul, Chuang, Lin, Xiao, Wang, Zhu, Lin, Wyatt, Parrington, Ma, Evans, Galione, Zhu: NAADP mobilizes calcium from acidic organelles through two-pore channels. in Nature 2009 (PubMed)

Weitere Antikörper gegen TPCN2 Interaktionspartner

Zebrafish Two Pore Segment Channel 2 (TPCN2) Interaktionspartner

  1. localized calcium (Ca(2 (zeige CA2 Antikörper)+)) release via TPC2 might trigger the generation of more global Ca(2 (zeige CA2 Antikörper)+) release from the sarcoplasmic reticulum via Ca(2 (zeige CA2 Antikörper)+)-induced Ca(2 (zeige CA2 Antikörper)+) release.

  2. TPC2-mediated Ca(2 (zeige CA2 Antikörper)+) release from lysosomes may act upstream from RyR (zeige RYR1 Antikörper)- and IP 3R-mediated Ca(2 (zeige CA2 Antikörper)+) release, suggesting that the former might initiate the SR-mediated Ca(2 (zeige CA2 Antikörper)+)-induced-Ca(2 (zeige CA2 Antikörper)+)-release essential for SMC (zeige DYM Antikörper) myogenesis and function.

Human Two Pore Segment Channel 2 (TPCN2) Interaktionspartner

  1. These findings indicate potential differential regulation of signaling processes by TPC1 (zeige TPCN1 Antikörper) and TPC2 in breast cancer cells.

  2. TPC2 regulates pigmentation through two fundamental determinants of melanosome function: pH and size.

  3. Results show that PDGs use previously unknown mechanisms of membrane dynamics and content exchange that are regulated by TPC2.

  4. Here, using live cell imaging, the authors obtained evidence that in contrast to the new model, ebolavirus enters cells through endolysosomes that contain both NPC1 (zeige NPC1 Antikörper) and TPC2.

  5. Studies suggest that both two-pore channels TPC1 (zeige TPCN1 Antikörper) and TPC2 as nicotinic acid adenine dinucleotide phosphate (NAADP) targets.

  6. TPC2 is thus a potential drug target within a pathogenic LRRK2 (zeige LRRK2 Antikörper) cascade that disrupts Ca(2 (zeige CA2 Antikörper)+)-dependent trafficking in Parkinson disease

  7. SNPs within Tpcn2 are associated with fasting insulin in humans.

  8. NAADP induced marked Ca(2 (zeige CA2 Antikörper)+) transients in HEK293 cells that stably coexpressed hTPC2 with hTPC1 or cTPC3, but failed to evoke any such response in cells that coexpressed interacting hTPC2 and rTPC3 subunits

  9. TPC2, but not TPC1 (zeige TPCN1 Antikörper), caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation.

  10. These results demonstrate that a VEGFR2/NAADP/TPC2/Ca(2+) signaling pathway is critical for VEGF-induced angiogenesis

Mouse (Murine) Two Pore Segment Channel 2 (TPCN2) Interaktionspartner

  1. High TPC2 expression is associated with lung metastasis in breast cancer.

  2. Electron micrographs of hearts from TPC1 (zeige TPCN1 Antikörper)/TPC2 double knockout mice showed that cardiomyocytes contained large numbers of immature lysosomes compared to wild-type mice.

  3. observations define a role for NAADP and TPC2 at lysosomal/sarcoplasmic reticulum junctions as unexpected but major contributors in the acute actions of beta-adrenergic signaling in the heart

  4. TPC2 plays a crucial role in trafficking in the endolysosomal degradation pathway and in fatty liver disease.

  5. Genetic ablation of endolysosomal TPC1 (zeige TPCN1 Antikörper) or TPC2 channels attenuates glucose- and sulfonylurea-induced membrane currents, depolarization, cytoplasmic Ca2 (zeige CA2 Antikörper)+ signals, and insulin (zeige INS Antikörper) secretion in pancreatic beta cells.

  6. Tpcn2 knockout mice demonstrated a significant decrease in fasting glucose levels and insulin (zeige INS Antikörper) response to a glucose challenge.

  7. Mice lacking TPC2 display muscle atrophy and altered autophagy.

  8. It was concluded that Tpcn1 (zeige TPCN1 Antikörper)/2(-/-) mice show mature-onset obesity due to reduced lipid availability and use, and a defect in beta-adrenergic receptor signaling, leading to impaired thermogenic activity, in brown adipose tissue.

  9. These results demonstrate that a VEGFR2/NAADP/TPC2/Ca(2+) signaling pathway is critical for VEGF-induced angiogenesis

  10. Findings indicate that TPC2 have important but distinct roles from TPC1 (zeige TPCN1 Antikörper) in the endo-lysosomal pathway.

TPCN2 Antigen-Profil

Protein Überblick

This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.

Genbezeichner und Symbole assoziert mit TPCN2

  • two pore segment channel 2 (tpcn2) Antikörper
  • two pore segment channel 2 (Tpcn2) Antikörper
  • two pore segment channel 2 (TPCN2) Antikörper
  • two pore segment channel 2 L homeolog (tpcn2.L) Antikörper
  • two pore calcium channel protein 2 (LOC100444397) Antikörper
  • BC025890 Antikörper
  • D830047E22Rik Antikörper
  • fi42c05 Antikörper
  • im:7140344 Antikörper
  • MGC115225 Antikörper
  • SHEP10 Antikörper
  • TPC2 Antikörper
  • wu:fi42c05 Antikörper
  • zgc:152898 Antikörper

Bezeichner auf Proteinebene für TPCN2

two pore calcium channel protein 2 , voltage-dependent calcium channel protein TPC2 , two pore segment channel 2 , two pore calcium channel protein 2-like , two-pore calcium channel protein 2

GENE ID SPEZIES
777614 Danio rerio
309139 Rattus norvegicus
423141 Gallus gallus
483683 Canis lupus familiaris
734733 Xenopus laevis
747605 Pan troglodytes
100444397 Pongo abelii
100492057 Xenopus (Silurana) tropicalis
100523421 Sus scrofa
100565414 Anolis carolinensis
219931 Homo sapiens
233979 Mus musculus
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