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TP53BP2 encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. Zusätzlich bieten wir Ihnen Tumor Protein P53 Binding Protein 2 Proteine (3) und Tumor Protein P53 Binding Protein 2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal TP53BP2 Primary Antibody für IF, WB - ABIN968491
Iwabuchi, Li, Massa, Trask, Date, Fields: Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. in The Journal of biological chemistry 1998
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Human Polyclonal TP53BP2 Primary Antibody für IF (p), IHC (p) - ABIN674394
Xie, Yang, Chi, Yang, Wang, Xu: Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study. in Chinese journal of cancer 2017
Human Polyclonal TP53BP2 Primary Antibody für IHC, ELISA - ABIN1584022
Matsumoto, Weckbecker, Cory: Antineoplastic effect of the combination of 2,3-dihydro-1H-pyrazole[2,3a]imidazole plus deoxyadenosine/erythro-9-(2-hydroxyl-3-nonyl)adenine in mice with L1210 leukemia cells. in Cancer communications 1990
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These findings uncover a novel role of Aspp2 in regulating vertebrate embryonic growth.
These findings identify TP53BP2 as a strong candidate causative gene for central nervous system (CNS) defects in 1q41q42 microdeletion syndrome.
SPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.
After genotoxic stress, Aspp1 (zeige PPP1R13B Antikörper) promotes hematopoietic stem cell (HSC (zeige FUT1 Antikörper)) cycling and induces p53 (zeige TP53 Antikörper)-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 (zeige PPP1R13B Antikörper) also attenuates HSC (zeige FUT1 Antikörper) self-renewal and accumulation of DNA damage in p53 (zeige TP53 Antikörper) null HSCs.
ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.
ASPP2 prevents beta-catenin (zeige CTNNB1 Antikörper) from transactivating ZEB1 (zeige ZEB1 Antikörper) directly by forming an ASPP2-beta-catenin (zeige CTNNB1 Antikörper)-E-cadherin (zeige CDH1 Antikörper) ternary complex
findings suggest that the identified STAT1 (zeige STAT1 Antikörper)/ASPP2 pathway may connect tumor suppression and cell polarity to neuroinflammation
our studies demonstrate the role of Siah2 (zeige SIAH2 Antikörper) in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability.
ASPP2 is a tumor suppressor that suppresses squamous cell carcinoma via inflammatory signaling through NF-kappaB (zeige NFKB1 Antikörper)-mediated repression of p63 (zeige CKAP4 Antikörper).
Our study demonstrates a novel role for ASPP1 (zeige PPP1R13B Antikörper) and ASPP2 in the death of retinal ganglion cells.
regulates epithelial cell polarity in cooperation with PAR-3 (zeige F2RL2 Antikörper) to form an active PAR (zeige AFG3L2 Antikörper) complex
Results showed that protein expression levels of ASPP2 and P53 (zeige TP53 Antikörper) were significantly higher in esophageal squamous cell carcinoma tissues than in paired noncancerous tissues.
Expression levels of TP53BP2, FBXO28 (zeige FBXO28 Antikörper), and FAM53A (zeige Fam53a Antikörper) genes were associated with patient survival specifically in ER-positive, TP53 (zeige TP53 Antikörper)-mutated tumors.
These data together implicated a critical impact of MiR (zeige MLXIP Antikörper)-205/ASPP2 on promoting epithelial-mesenchymal transition.
ASPP2 is a key regulator of BECN1 (zeige BECN1 Antikörper)-dependent autophagy.
ASPP2 suppresses invasion, peritoneal dissemination and TGF-beta1 (zeige TGFB1 Antikörper)-induced EMT (zeige ITK Antikörper) by inhibiting Smad7 (zeige SMAD7 Antikörper) degradation mediated by ITCH in gastric cancer cells.
Our results suggest that Gal-1 and ASPP2 functionally compete in nanocluster for active Ras on the plasma membrane. ASPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.
ASPP2 suppresses p53 (zeige TP53 Antikörper) target gene transactivation, promoter occupancy, and endogenous p53 (zeige TP53 Antikörper) target gene expression in response to DNA damage
In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin (zeige AREG Antikörper) expression in a p53 (zeige TP53 Antikörper)-dependent manner
Downregulated expression of ASPP2 is associated with hepatocellular carcinoma.
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.
tumor protein p53 binding protein, 2
, apoptosis-stimulating of p53 protein 2-like
, apoptosis-stimulating of p53 protein 1
, protein phosphatase 1 regulatory subunit 13B
, transformation related protein 53 binding protein 2
, tumor protein p53-binding protein, 2
, apoptosis-stimulating of p53 protein 2
, p53-binding protein 2
, tumor suppressor p53-binding protein 2
, BCL2-binding protein
, apoptosis-stimulating protein of p53, 2
, renal carcinoma antigen NY-REN-51