TP53BP2 Antikörper (Internal Region)

Produktnummer ABIN233802

Produktdetails anti-TP53BP2 Antikörper

Target: TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TP53BP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human ASPP2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 125 kDa in size corresponding to ASPP2 by western blotting in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2.4 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu TP53BP2

Target: TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))

Andere Bezeichnung: ASPP2 (TP53BP2 Produkte)

Synonyme: 53BP2 antikoerper, ASPP2 antikoerper, BBP antikoerper, P53BP2 antikoerper, PPP1R13A antikoerper, TP53BP2 antikoerper, AI746547 antikoerper, Tp53bp2 antikoerper, X98550 antikoerper, Trp53bp2 antikoerper, wu:fa09h08 antikoerper, wu:fb04e08 antikoerper, zgc:85720 antikoerper, tumor protein p53 binding protein 2 antikoerper, tumor protein p53 binding protein 2 L homeolog antikoerper, tumor protein p53 binding protein, 2b antikoerper, transformation related protein 53 binding protein 2 antikoerper, tumor protein p53 binding protein, 2 antikoerper, tumor protein p53 binding protein, 2a antikoerper, TP53BP2 antikoerper, tp53bp2.L antikoerper, tp53bp2 antikoerper, tp53bp2b antikoerper, Trp53bp2 antikoerper, Tp53bp2 antikoerper, tp53bp2a antikoerper

Hintergrund: ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.  In contrast, iASPP functionally inactivates p53.  ASPPs may also regulate p63- and p73-mediated apoptosis.  Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3.  Not all cell cycle arrest genes are affected, such as p21.  Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.  Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
Synonyms: Apoptosis stimulating of p53 protein 2 antibody, Bbp antibody, Bcl2 binding protein antibody, NY REN 51 antigen antibody, p53 binding protein 2 antibody

Gen-ID: 7159, 112799849

UniProt: Q13625