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TPM4 encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Zusätzlich bieten wir Ihnen Tropomyosin 4 Proteine (14) und Tropomyosin 4 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal TPM4 Primary Antibody für IF, IHC (p) - ABIN563237
Häbig, Gellhaar, Heim, Djuric, Giesert, Wurst, Walter, Hentrich, Riess, Bonin: LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4. in Biochimica et biophysica acta 2013
findings demonstrate a nonredundant role for TPM4 in platelet biogenesis in humans and mice and reveal that truncating variants in TPM4 cause a previously undescribed dominant Mendelian platelet disorder.
In diabetes, expression of high molecular weight (HMW) isoforms from tropomyosin 1 (TPM1 (zeige TPM1 Antikörper)) were markedly decreased but HMW isoforms from tropomyosin 4 (TPM4) were not significantly different.
Results show that Tpm4.2 facilitates the transition of NM-2A to the strongly actin-binding myosin-ADP state.
In addition to CLIC1 (zeige CLIC1 Antikörper) and TPM1 (zeige TPM1 Antikörper), which were the proteins initially discovered in a xenograft mouse model, CLIC4 (zeige CLIC4 Antikörper), TPM2 (zeige TPM2 Antikörper), TPM3 (zeige TPM3 Antikörper), and TPM4 were present in ovarian cancer patient sera at significantly elevated levels compared with controls.
Data indicate the upregulation of tropomyosin-4 in infiltrating ductal breast carcinomas (IDCAs) tissues, which may suggest its involvement in breast cancer development.
Plasma peroxiredoxins 1 and 2, and tropomyosin 4 were shown to associate with asbestos-exposure, and peroxiredoxin 1 (zeige PRDX1 Antikörper) with lung cancer.
TPM4, PDIA and SRC8 were also localized to the trophoblast cells, further highlighting the importance of these cytoskeletal remodelling proteins in early pregnancy
Low TPM4 expression in the cytoplasm is associated with uterine cervix carcinogenesis.
Tm4-defined cytoskeleton is a marker of growth and repair/regeneration in response to injury, disease state and stress in skeletal muscle.
Tm-4 is specifically enriched within and around osteoclast attachment structures, the sealing zone and podosomes.
Tropomyosin 4 defines longitudinal filaments in mouse models of muscular dystrophy and nemaline myopathy.
These results indicate that Tm-4 plays a role in regulating adhesion structures of osteoclasts, most likely by stabilizing the actin microfilaments present in podosomes and the sealing zone.
upregulation of tropomyosin 4 (TM4) mRNA is a relevant marker of dedifferentiation in vascular smooth muscle cells.
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene.
, tropomyosin alpha-4 chain
, tropomycin 4