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The protein encoded by TRIM6 is a member of the tripartite motif (TRIM) family. Zusätzlich bieten wir Ihnen TRIM6 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Intriguingly, the authors also found that TRIM6 enhances ebola virus polymerase activity in a minigenome assay and TRIM6 knockout cells have reduced replication of infectious ebola virus, suggesting that VP35 hijacks TRIM6 to promote ebola virus replication through ubiquitination.
Live NiV infection, but not a recombinant NiV lacking the M protein (zeige MYOM2 Antikörper), reduced the levels of endogenous TRIM6 protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6, IKKepsilon (zeige IKBKE Antikörper) and unanchored polyubiquitin (zeige UBB Antikörper) chains.
TRIM6 and the E2-ubiquitin conjugase (zeige GGH Antikörper) UbE2K (zeige UBE2K Antikörper) cooperated in the synthesis of unanchored K48-linked polyubiquitin (zeige UBB Antikörper) chains, which activated IKKepsilon (zeige IKBKE Antikörper) for subsequent STAT1 (zeige STAT1 Antikörper) phosphorylation.
heterologous RING, B-box 2, and CC domains from related TRIM (zeige TRAT1 Antikörper) proteins can functionally substitute for TRIM5alpha (zeige TRIM5 Antikörper)(rh) domains.
TRIM6 regulates the transcriptional activity of Myc (zeige MYC Antikörper) during the maintenance of cell pluripotency, suggesting that TRIM6 functions as a novel regulator for Myc (zeige MYC Antikörper)-mediated transcription in embryonic stem cells.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members.
tripartite motif-containing 6
, tripartite motif-containing 6, isoform 2
, tripartite motif-containing protein 6-like
, tripartite motif-containing protein 6
, tripartite motif containing 6
, RING finger protein 89
, tripartite motif protein 6