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TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. Zusätzlich bieten wir Ihnen TREM2 Antikörper (177) und TREM2 Kits (22) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) TREM2 Protein expressed in Human Cells - ABIN2007407
Bouchon, Dietrich, Colonna: Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. in Journal of immunology (Baltimore, Md. : 1950) 2000
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Human TREM2 Protein expressed in Human Cells - ABIN2003942
Paloneva, Manninen, Christman, Hovanes, Mandelin, Adolfsson, Bianchin, Bird, Miranda, Salmaggi, Tranebjaerg, Konttinen, Peltonen: Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. in American journal of human genetics 2002
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flow cytometry analyses indicated significantly lower surface expression of T66M TREM2 variant than wild type or other TREM2 variants
silencing TREM-2 downregulated the expression levels of Bcl2 (zeige BCL2 Proteine) and PCNA (zeige PCNA Proteine), and upregulated the expression levels of Bax (zeige BAX Proteine) and caspase-3 (zeige CASP3 Proteine) in renal cell carcinoma (zeige MOK Proteine) cells. Depletion of TREM-2 inactivated PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) pathway through increasing the expression of PTEN. TREM-2 acts as an oncogene (zeige RAB1A Proteine) in the development of renal cell carcinoma (zeige MOK Proteine) and can be considered as a novel therapeutic factor in the treatment of renal cell carcinoma (zeige MOK Proteine).
TREM2 expression is significantly upregulated in human masticatory mucosa during wound healing
this study shows that activation of TREM-2 may restrain h-MSC (zeige MSC Proteine) immune activation and promote differentiation for tissue repair
The TREM family members are also considered to involve in Alzheimer's disease (AD) and cerebrospinal fluid (CSF (zeige CSF2 Proteine)) soluble form of TREM2 (sTREM2) levels has also been associated with respond to progression of disease.
Study provides evidence that TREM2 mRNA is upregulated in the human hippocampus affected by Alzheimer's disease (AD). Findings also suggest that 5hmC may play a role in regulating TREM2 mRNA expression in AD hippocampus.
The study suggests that TREM2 may work as an oncogene (zeige RAB1A Proteine) and a new effective therapeutic target for glioma treatment.
CSF (zeige CSF2 Proteine) concentrations of soluble TREM2 are higher in Alzheimer's disease than in controls
Variant p.R47H of TREM2 was not associated with Parkinson's disease
Our results corroborate and extend previous findings, concluding that the variant rs75932628-T (p.R47H) in TREM2 is not a risk factor for leucoaraiosis or Parkinson's disease in the Han Chinese population.
Study found that TREM2 was upregulated in the brain of P301S mice, an animal model of tau pathology, during disease progression and showed that TREM2 overexpression rescued spatial cognitive impairments and ameliorated neuropathologies including neuronal and synaptic loss as well as tau hyperphosphorylation.
This study showed that TREM-2 deficiency restricts the inflammatory response, thereby decreasing organ damage and mortality.
TREM2 attenuates tau kinase activity through restriction of neuroinflammation, and thus protects against tau pathology.
TREM2 is involved in prion (zeige PRNP Proteine)-induced microglial activation but does not noticeably modulate the pathogenesis of experimental prion (zeige PRNP Proteine) infections.
These findings provide a novel interpretation of Brucella intracellular growth through inhibition of NO production produced by TREM-2-mediated activated macrophages.
TREM-1 (zeige TREM1 Proteine)/TREM-3 macrophage expression improved host defense against Klebsiella-derived pneumosepsis, whereas TREM-2 did not have a role.
These findings place TREM2 as a key regulator of microglia activation in vivo in response to tissue damage
TREM-2 has a protective effect on inflammatory response of endotoxin-induced acute lung injury in mice.
results support a role of DAP12 (zeige TYROBP Proteine) in stabilizing TREM2-CTF (zeige NFIA Proteine), thereby protecting against excessive pro-inflammatory responses.
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.
triggering receptor expressed on myeloid cells 2
, triggering receptor expressed on monocytes 2
, triggering receptor expressed on myeloid cells 2a
, triggering receptor expressed on myeloid cells 2b
, triggering receptor expressed on myeloid cells 2c