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Triggering Receptor Expressed On Myeloid Cells 2 Proteine (TREM2)

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. Zusätzlich bieten wir Ihnen TREM2 Antikörper (177) und TREM2 Kits (22) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  
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Showing 10 out of 14 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Maus Fc Tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
Details
HOST_Human Cells Human His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
395,77 €
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Mammalian Cells Maus Fc Tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
341,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 6 bis 8 Tage
403,06 €
Details

TREM2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine) , , ,
, , ,
Rat (Rattus)

Am meisten referenzierte TREM2 Proteine

  1. Mouse (Murine) TREM2 Protein expressed in Human Cells - ABIN2007407 : Bouchon, Dietrich, Colonna: Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. in Journal of immunology (Baltimore, Md. : 1950) 2000 (PubMed)
    Zeige alle 2 Referenzen für ABIN2007407

  2. Human TREM2 Protein expressed in Human Cells - ABIN2003942 : Paloneva, Manninen, Christman, Hovanes, Mandelin, Adolfsson, Bianchin, Bird, Miranda, Salmaggi, Tranebjaerg, Konttinen, Peltonen: Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. in American journal of human genetics 2002 (PubMed)
    Zeige alle 2 Referenzen für ABIN2003942

Weitere Proteine zu Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Interaktionspartnern

Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Interaktionspartner

  1. flow cytometry analyses indicated significantly lower surface expression of T66M TREM2 variant than wild type or other TREM2 variants

  2. silencing TREM-2 downregulated the expression levels of Bcl2 (zeige BCL2 Proteine) and PCNA (zeige PCNA Proteine), and upregulated the expression levels of Bax (zeige BAX Proteine) and caspase-3 (zeige CASP3 Proteine) in renal cell carcinoma (zeige MOK Proteine) cells. Depletion of TREM-2 inactivated PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) pathway through increasing the expression of PTEN. TREM-2 acts as an oncogene (zeige RAB1A Proteine) in the development of renal cell carcinoma (zeige MOK Proteine) and can be considered as a novel therapeutic factor in the treatment of renal cell carcinoma (zeige MOK Proteine).

  3. TREM2 expression is significantly upregulated in human masticatory mucosa during wound healing

  4. this study shows that activation of TREM-2 may restrain h-MSC (zeige MSC Proteine) immune activation and promote differentiation for tissue repair

  5. The TREM family members are also considered to involve in Alzheimer's disease (AD) and cerebrospinal fluid (CSF (zeige CSF2 Proteine)) soluble form of TREM2 (sTREM2) levels has also been associated with respond to progression of disease.

  6. Study provides evidence that TREM2 mRNA is upregulated in the human hippocampus affected by Alzheimer's disease (AD). Findings also suggest that 5hmC may play a role in regulating TREM2 mRNA expression in AD hippocampus.

  7. The study suggests that TREM2 may work as an oncogene (zeige RAB1A Proteine) and a new effective therapeutic target for glioma treatment.

  8. CSF (zeige CSF2 Proteine) concentrations of soluble TREM2 are higher in Alzheimer's disease than in controls

  9. Variant p.R47H of TREM2 was not associated with Parkinson's disease

  10. Our results corroborate and extend previous findings, concluding that the variant rs75932628-T (p.R47H) in TREM2 is not a risk factor for leucoaraiosis or Parkinson's disease in the Han Chinese population.

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Interaktionspartner

  1. flow cytometry analyses indicated significantly lower surface expression of T66M TREM2 variant than wild type or other TREM2 variants

  2. Study found that TREM2 was upregulated in the brain of P301S mice, an animal model of tau pathology, during disease progression and showed that TREM2 overexpression rescued spatial cognitive impairments and ameliorated neuropathologies including neuronal and synaptic loss as well as tau hyperphosphorylation.

  3. This study showed that TREM-2 deficiency restricts the inflammatory response, thereby decreasing organ damage and mortality.

  4. TREM2 attenuates tau kinase activity through restriction of neuroinflammation, and thus protects against tau pathology.

  5. TREM2 is involved in prion (zeige PRNP Proteine)-induced microglial activation but does not noticeably modulate the pathogenesis of experimental prion (zeige PRNP Proteine) infections.

  6. These findings provide a novel interpretation of Brucella intracellular growth through inhibition of NO production produced by TREM-2-mediated activated macrophages.

  7. TREM-1 (zeige TREM1 Proteine)/TREM-3 macrophage expression improved host defense against Klebsiella-derived pneumosepsis, whereas TREM-2 did not have a role.

  8. These findings place TREM2 as a key regulator of microglia activation in vivo in response to tissue damage

  9. TREM-2 has a protective effect on inflammatory response of endotoxin-induced acute lung injury in mice.

  10. results support a role of DAP12 (zeige TYROBP Proteine) in stabilizing TREM2-CTF (zeige NFIA Proteine), thereby protecting against excessive pro-inflammatory responses.

TREM2 Protein Überblick

Protein Überblick

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2)
  • triggering receptor expressed on myeloid cells 2 (trem2)
  • triggering receptor expressed on myeloid cells 2 (LOC100228399)
  • triggering receptor expressed on myeloid cells 2 (Trem2)
  • TREM-2 Protein
  • TREM-A1 Protein
  • TREM-B1 Protein
  • TREM2 Protein
  • Trem2a Protein
  • Trem2b Protein
  • Trem2c Protein

Bezeichner auf Proteinebene für TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

GENE ID SPEZIES
419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
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