Triggering Receptor Expressed On Myeloid Cells 2 Proteine (TREM2)

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. Zusätzlich bieten wir Ihnen TREM2 Antikörper (192) und TREM2 Kits (24) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  
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Showing 10 out of 14 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Maus Fc Tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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HOST_Human Cells Human His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
395,77 €
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Mammalian Cells Maus His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
341,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 6 bis 8 Tage
403,06 €
Details

TREM2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine) , , ,
, , ,
Rat (Rattus)

Am meisten referenzierte TREM2 Proteine

  1. Mouse (Murine) TREM2 Protein expressed in Human Cells - ABIN2007407 : Bouchon, Dietrich, Colonna: Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. in Journal of immunology (Baltimore, Md. : 1950) 2000 (PubMed)
    Zeige alle 2 Referenzen für 2007407

  2. Human TREM2 Protein expressed in Human Cells - ABIN2003942 : Paloneva, Manninen, Christman, Hovanes, Mandelin, Adolfsson, Bianchin, Bird, Miranda, Salmaggi, Tranebjaerg, Konttinen, Peltonen: Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. in American journal of human genetics 2002 (PubMed)
    Zeige alle 2 Referenzen für 2003942

Weitere Proteine zu Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Interaktionspartnern

Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Interaktionspartner

  1. Found increased Alzheimer's disease risk associated with several TREM2 variants, and show that these variants decreased or markedly increased binding to TREM2 ligands. Results suggest that TREM2 signaling helps protect against Alzheimer's disease but can cause harm in excess (zeige RCC1 Proteine), supporting the idea that proper TREM2 function is important to counteract disease progression.

  2. SNPs involved in pathways related to virus cellular entry and vesicular trafficking were overrepresented, suggesting that cerebrospinal fluid soluble TREM2 levels could be an informative phenotype for Alzheimer disease

  3. Rare coding variants of TREM2 may play an important role in AD in Han Chinese.

  4. These data demonstrate that cerebrospinal fluid soluble TREM2 levels are increased in the early symptomatic phase of Alzheimer's disease, probably reflecting a corresponding change of the microglia activation status in response to neuronal degeneration.

  5. link three genetic risk factors for Alzheimer's disease and reveal a possible mechanism by which mutant TREM2 increases risk of AD

  6. Microglia in Alzheimer's disease (AD) patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (ER) stress. Study concludes that TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism.

  7. TREM2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation

  8. flow cytometry analyses indicated significantly lower surface expression of T66M TREM2 variant than wild type or other TREM2 variants

  9. silencing TREM-2 downregulated the expression levels of Bcl2 (zeige BCL2 Proteine) and PCNA (zeige PCNA Proteine), and upregulated the expression levels of Bax (zeige BAX Proteine) and caspase-3 (zeige CASP3 Proteine) in renal cell carcinoma (zeige MOK Proteine) cells. Depletion of TREM-2 inactivated PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) pathway through increasing the expression of PTEN. TREM-2 acts as an oncogene (zeige RAB1A Proteine) in the development of renal cell carcinoma (zeige MOK Proteine) and can be considered as a novel therapeutic factor in the treatment of renal cell carcinoma (zeige MOK Proteine).

  10. TREM2 expression is significantly upregulated in human masticatory mucosa during wound healing

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Interaktionspartner

  1. Loss of TREM2 reduces the ability of microglia to engulf amyloid beta-peptide.

  2. TREM2 and TREML2 (zeige TREML2 Proteine) play opposite roles in microglia activation.

  3. Our study suggests that Vps35 (zeige vps35 Proteine)/retromer is responsible for recycling of Trem2 in the regulation of microglial function such as proinflammatory responses, whereas R47H mutation impairs Trem2 trafficking, which might contribute to Alzheimer disease.

  4. Microglia in Alzheimer's disease (AD) patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (ER) stress. Study concludes that TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism.

  5. This study demonstrate a critical role of TREM2-mediated Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway in microglial viability and suggest that modulating this pathway therapeutically may help to combat the impaired microglial survival.

  6. Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoglobulin-like receptor of the TREM family and is expressed on activated macrophages, immature dendritic cells, osteoclasts, and microglia.

  7. TREM2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation

  8. TREM2 deficiency has opposing effects on Alzheimer's disease-related pathologies at early and late stages of disease progression.

  9. TREM2 protects from Alzheimer's disease by enabling microglia to surround and alter Abeta (zeige APP Proteine) plaque structure, thereby limiting neuritic damage.

  10. Recent studies have revealed that activated microglia in the spinal dorsal horn exacerbate neuropathic pain, which has suggested that suppression of microglial activity should be considered as a therapeutic target. However, only a few molecules have been identified as regulators of microglial activity. In this study, we focused on a receptor complex of TREM2 and DAP12 (zeige TYROBP Proteine), both of which are expressed by microglia and have bee

TREM2 Protein Überblick

Protein Überblick

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2)
  • triggering receptor expressed on myeloid cells 2 (trem2)
  • triggering receptor expressed on myeloid cells 2 (LOC100228399)
  • triggering receptor expressed on myeloid cells 2 (Trem2)
  • TREM-2 Protein
  • TREM-A1 Protein
  • TREM-B1 Protein
  • TREM2 Protein
  • Trem2a Protein
  • Trem2b Protein
  • Trem2c Protein

Bezeichner auf Proteinebene für TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

GENE ID SPEZIES
419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
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