anti-Transmembrane Channel-Like 8 (TMC8) Antikörper

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Zusätzlich bieten wir Ihnen TMC8 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TMC8 147138 Q8IU68
TMC8 688276  
TMC8 217356 Q7TN58
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Top anti-TMC8 Antikörper auf antikoerper-online.de

Showing 10 out of 65 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human tonsil, using TMC8 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Kaninchen Unkonjugiert WB WB Suggested Anti-TMC8 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: 721_B cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB   100 μg Anmelden zum Anzeigen 11 bis 15 Tage
425,76 €
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Human Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 11 bis 15 Tage
425,76 €
Details
Human Kaninchen Unkonjugiert WB TMC8 Antibody (N-term) (ABIN658164) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the TMC8 antibody detected the TMC8 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: EVER2 Antibody [NBP1-76903] - Human Brain cells. Western Blot: EVER2 Antibody [NBP1-76903] - Jurkat cell lysate with EVER2 antibody at (A) 1 and (B) 2 ug/ml. 0.1 mg Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 13 Days
154,33 €
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Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
635,55 €
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
387,62 €
Details

TMC8 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-TMC8 Antikörper

  1. Human Polyclonal TMC8 Primary Antibody für IHC, ELISA - ABIN1002274 : Ramoz, Taïeb, Rueda, Montoya, Bouadjar, Favre, Orth: Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25. in The Journal of investigative dermatology 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal TMC8 Primary Antibody für ELISA, WB - ABIN1002275 : Ramoz, Rueda, Bouadjar, Montoya, Orth, Favre: Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. in Nature genetics 2002 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen TMC8 Interaktionspartner

Human Transmembrane Channel-Like 8 (TMC8) Interaktionspartner

  1. The present study did not show any significant association of the EVER1 (zeige TMC6 Antikörper)/2 polymorphisms (rs2290907and rs16970849) with cervical cancer.

  2. There were no differences in Ever2 SNPs between head and neck squamous cell carcinoma patients with human papilloma virus (HPV)-positive and HPV-negative tumors, and healthy controls.

  3. Findings suggest that SNPs in EVER2 may be involved in the development of premalignant skin lesions that harbour beta-HPV, perhaps giving rise to SCC (zeige CYP11A1 Antikörper) tumours that have lost beta-HPV gene expression during progression.

  4. TMC6/EVER1 (zeige TMC6 Antikörper) and TMC8/EVER2 are known to be involved in the development of EV.

  5. A common genetic variation in TMC8 is associated with high-risk HPV infection and head and neck squamous cell carcinoma etiology.

  6. We found a possible correlation between the EVER2 TT genotype and the development of AK, suggesting a potential role of this polymorphism in the development of AK.

  7. EV is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 (zeige TMC6 Antikörper) or EVER2.

  8. TMC8 was found to be localized in the endoplasmic reticulum (ER), where it inhibited receptor mediated Ca(2 (zeige CA2 Antikörper)+) release, activation of Ano1 (zeige ANO1 Antikörper) and volume regulated LRRC8 (zeige LRRC8A Antikörper)-related Cl(-) currents.

  9. Expression of both EVER1 (zeige TMC6 Antikörper) and EVER2 in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed by latent membrane protein 1-activated NF-kappaB (zeige NFKB1 Antikörper) signaling.

  10. Loss of the HPV-infection resistance EVER2 protein impairs NF-kappaB (zeige NFKB1 Antikörper) signaling pathways in keratinocytes.

TMC8 Antigen-Profil

Protein Überblick

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.

Genbezeichner und Symbole assoziert mit TMC8

  • transmembrane channel-like 8 (TMC8) Antikörper
  • transmembrane channel-like 8 (Tmc8) Antikörper
  • transmembrane channel-like gene family 8 (Tmc8) Antikörper
  • EV2 Antikörper
  • Ever2 Antikörper
  • EVIN2 Antikörper
  • mFLJ00400 Antikörper

Bezeichner auf Proteinebene für TMC8

transmembrane channel-like 8 , FLJ00400 protein-like , transmembrane channel-like protein 8-like , epidermodysplasia verruciformis 2 , epidermodysplasia verruciformis protein 2 , transmembrane channel-like protein 8 , uncharacterized protein LOC688276 , epidermodysplasia verruciformis protein 2 homolog

GENE ID SPEZIES
483342 Canis lupus familiaris
513813 Bos taurus
100031099 Monodelphis domestica
100443950 Pongo abelii
100478575 Ailuropoda melanoleuca
100596943 Nomascus leucogenys
100615612 Pan troglodytes
147138 Homo sapiens
688276 Rattus norvegicus
217356 Mus musculus
Ausgewählte Anbieter für anti-TMC8 (TMC8) Antikörper
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