TMC8 Antikörper (Center)

Produktnummer ABIN499810

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TMC8 in WB, IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für TMC8 Antikörper (Center) (ABIN499810)

Target: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMC8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-TMC8 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody reacts to EVER2.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: EVER2 antibody was raised against a 14 amino acid peptide from near the center of human EVER2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blt: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu TMC8

Target: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Andere Bezeichnung: TMC8

Hintergrund: Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least three isoforms of EVER2 are known to exist, this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.Synonyms: EVER2, EVIN2, Epidermodysplasia verruciformis protein 2, Transmembrane channel-like protein 8

Gen-ID: 147138

UniProt: Q8IU68