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TSN encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Zusätzlich bieten wir Ihnen Translin Antikörper (55) und Translin Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Study describes the identification of translin (trsn), a highly conserved RNA/DNA binding protein (zeige CNBP Proteine), as essential for starvation-induced sleep suppression. Strikingly, trsn does not appear to regulate energy stores, free glucose levels, or feeding behavior suggesting the sleep phenotype of trsn mutant flies is not a consequence of general metabolic dysfunction or blunted response to starvation.
These studies establish that Trax (zeige TSNAX Proteine) adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly.
Drosophila translin exhibits a stable dimeric state that assembles into a suboctameric (tetramer/hexamer) form and fails (zeige AK3 Proteine) to bind ssDNA and RNA targets
A translin null mutant was generated and a trax (zeige TSNAX Proteine) nonsense mutation was isolated. Translin is essential for stabilizing its interaction with trax (zeige TSNAX Proteine).
Drosophila translin may have roles in neuronal development and behavior analogous to that of mouse translin.
Results suggest that the oligomeric status of translin critically influences the DNA binding properties of translin proteins.
an RNAi regulator that we term C3PO (component 3 promoter of RISC), a complex of Translin and Trax was purified; C3PO is a Mg2+-dependent endoribonuclease that promotes RISC activation by removing siRNA passenger strand cleavage products
results indicate that UPF1 (zeige UPF1 Proteine) can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to Tudor-staphylococcal/micrococcal-like nuclease (zeige DCLRE1C Proteine) (TSN)-mediated miRNA decay.
These findings indicate that miRNA depletion in dicer (zeige DICER1 Proteine) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.
this study argues against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity.
The selectivity of PLCbeta toward certain genes lies in the rate at which the RNA is hydrolyzed by C3PO.
The data demonstrates that the configuration of translin and translin-RNA complexes in solution is a dimer of tetramers, which undergoes conformational transitions.
Translin B3 motif, corresponding to TRAX (zeige TSNAX Proteine) B3 residues, contributes towards its DNA binding activity.
C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX (zeige TSNAX Proteine) subunits which activates RISC by degrading the Ago2 (zeige EIF2C2 Proteine)-nicked passenger strand of siRNA.
Sedimentation equilibrium studies using fluorescein-labeled single-stranded DNA support a model in which translin forms an annular structure of eight subunits, an oblate ellipsoid that binds single-stranded DNA at chromosomal breakpoints.
study of reactivity of two -SH groups and stidu of proximity of Cys (zeige DNAJC5 Proteine)-225 residues
At high enough concentrations, translin binds duplex DNA by selectively loading from the free ends, which apparently results in clamping of strands at the duplex ends.
These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF (zeige BDNF Proteine) mRNA can be mediated by both translin-dependent and -independent mechanisms.
trax (zeige TSNAX Proteine) acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism.
TB-RBP is involved in the posttranscriptional regulation of Gapds (zeige GAPDHS Proteine) gene expression during spermiogenesis.
TB-RBP-null male mice were fertile and sired offspring but had abnormal seminiferous tubules and reduced sperm counts. Null female mice were subfertile, had reduced litter sizes; analysis of brain RNA from null mice revealed an altered gene expression
TB-RBP-mouse ribonucleoprotein complex transports a group of specific CREM (zeige CREM Proteine)-regulated mRNAs in mammalian male postmeiotic germ cells.
TB-RBP post-transcriptionally stabilizes TRAX (zeige TSNAX Proteine) and both proteins are needed for normal cell proliferation
subcellular locations of TB-RBP and TRAX (zeige TSNAX Proteine) in male germ cells are modulated by the relative ratios of TRAX (zeige TSNAX Proteine) and TB-RBP
During a search for RNA-induced silencing complex (RISC) proteins that directly interact with small interference RNA, the authors identify TB-RBP in NIH3T3 cell lysate and show that it possesses both single- and double-stranded RNase activities.
These studies have, for the first time, identified both mRNAs and a non-coding RNA as TSN targets expressed during meiosis
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants.
, testis-brain RNA binding protein
, component 3 of promoter of RISC
, recombination hotspot associated factor
, recombination hotspot-binding protein
, testis brain-RNA binding protein
, testis/brain RNA-binding protein
, testis/brain-RNA-binding protein
, translin protein