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The protein encoded by TLK1 is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. Zusätzlich bieten wir Ihnen Tousled-Like Kinase 1 Antikörper (116) und Tousled-Like Kinase 1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Human TLK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005117
Silljé, Nigg: Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. in Current biology : CB 2001
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TLK-1 contributes to chromosome condensation and segregation;TLK-1 functions in cytokinesis by localizing AIR-2 to the midzone microtubules.
Tousled-like kinase (TLK-1) contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase AIR-2.
Our results suggest that GA-mediated transient modulation of TLK1 activity promotes DNA repair and suppresses radiation cytoxicity in salivary gland cells.
TLK1B mediated phosphorylation of Rad9 (zeige RAD9A Proteine) regulates its nuclear/cytoplasmic localization and cell cycle checkpoint
Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a (zeige ASF1A Proteine) and Asf1b (zeige ASF1B Proteine) function.
Tousled-like kinase-dependent phosphorylation of Rad9 (zeige RAD9A Proteine) plays a role in cell cycle progression and G2/M checkpoint exit.
Adenoviral delivery of Tousled kinase protects salivary glands against ionizing radiation damage.
Silencing of TLK1 enhanced DNA damage induced by cisplatin treatment, suggesting that TLK1 plays a pivotal role for the repair of cisplatin-induced DNA damage.
ASF1 (zeige SRSF1 Proteine) cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 (zeige SRSF1 Proteine) and hASF1a (zeige ASF1A Proteine) by TLK (zeige TLK2 Proteine) kinases.
we show that Chk1 (zeige CHEK1 Proteine) is essential for the suppression of TLK (zeige TLK2 Proteine) activity after replication block, but that ATR (zeige ANTXR1 Proteine), Chk2 (zeige CHEK2 Proteine) and BRCA1 are dispensable for TLK (zeige TLK2 Proteine) suppression.
Both eIF4E (zeige EIF4E Proteine) and TLK1B are elevated in breast cancer specimens but not in benign breast specimens from noncancer patients. Degree of TLK1B elevation is correlated with degree of IF4E (zeige EIF4E2 Proteine) overexpression.
In addition, it could be demonstrated that increasing the Tlk1 activity in HT1080 (zeige CDC123 Proteine) cells by forced Tlk1 overexpression leads to an increased phosphorylation of endogenous p68 (zeige ANXA6 Proteine).
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
tousled-like kinase 1
, pKU-beta protein kinase
, serine/threonine-protein kinase tousled-like 1-B
, tousled-like kinase 1-B
, SNARE protein kinase SNAK
, serine threonine protein kinase
, serine/threonine-protein kinase tousled-like 1