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Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen TNIK Proteine (7) und TNIK Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal TNIK Primary Antibody für IHC (p), WB - ABIN392499
Wang, Charych, Pulito, Lee, Graziane, Crozier, Revilla-Sanchez, Kelly, Dunlop, Murdoch, Taylor, Xie, Pausch, Hayashi-Takagi, Ishizuka, Seshadri, Bates, Kariya, Sawa, Weinberg, Moss, Houslay, Yan et al.: The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. ... in Molecular psychiatry 2011
Show all 2 Pubmed References
Human Polyclonal TNIK Primary Antibody für ICC, IF - ABIN4361265
Yu, Zhang, Wang, Zhang, Chen, Hu, Dong, Zhu, Qian, Fan, Su, Xu, Zheng, Dong, Yin, Ji, Ji: The essential role of TNIK gene amplification in gastric cancer growth. in Oncogenesis 2014
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Human Monoclonal TNIK Primary Antibody für ELISA, WB - ABIN564994
Mahmoudi, Li, Ng, Taouatas, Vries, Mohammed, Heck, Clevers: The kinase TNIK is an essential activator of Wnt target genes. in The EMBO journal 2009
Human Monoclonal TNIK Primary Antibody für IF, WB - ABIN968788
Fu, Shen, Huang, Lasaga, Payan, Luo: TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. in The Journal of biological chemistry 1999
Exome sequencing of the index in each family revealed the same homozygous truncating mutation in TNIK that results in complete loss of the protein. TNIK is a kinase with a well-established role in dendrite development and synaptic transmission. The phenotype we observe in human patients who lack TNIK is consistent with the previously published Tnik (-/-) phenotype in the murine model
Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 (zeige MEIS1 Antikörper) , rs7633294 at 3p14.1 near MAGI1 (zeige MAGI1 Antikörper) and rs9810566 at 3q26.2 near TNIK
Our results demonstrated that TNIK might play a crucial role in pancreatic carcinogenesis and serve as a novel therapeutic target of pancreatic cancer.
High expression of TNIK in colorectal cancer was associated with recurrence in stage II and III colorectal cancer patients.
Endogenous substrates of TNIK were identified in neurons, along with consensus sequences for TNIK.
nuclear p-TNIK expression was studied in hepatocellular carcinoma, and p-TNIK nuclear expression was associated with poor prognosis and is a candidate prognostic marker for hepatocellular carcinoma
Dynamic change of TNIK offers a way to protect cells from outside stimulus.
TNIK mediates proliferation and survival of EBV-transformed B-cells.
TNIK is essential for the activation of both the canonical Wnt (zeige WNT2 Antikörper) pathway and the JNK (zeige MAPK8 Antikörper) pathway, and serves as a pro-survival factor.
TNIK is a specific effector of Rap2 to regulate actin cytoskeleton
This study demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain.
TNiK is required for dentate gyrus neurogenesis & for pattern separation in a 2-choice spatial discrimination task & for glutamate (zeige GRIN1 Antikörper)-dependent object-location paired associate learning.
TNIK maintains levels of glutamate receptors and other key postsynaptic density (PSD) proteins at the synapse, with loss of TNIK protein or inhibition of TNIK activity causing rapid degradation of PSD constituents.
siRNA depletion of TNIK followed by expression array analysis showed that TNIK is an essential, specific activator of Wnt (zeige WNT2 Antikörper) transcriptional programme.
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999
TRAF2 and NCK interacting kinase
, TRAF2 and NCK-interacting protein kinase-like
, TRAF2 and NCK-interacting protein kinase
, traf2 and NCK-interacting protein kinase
, Traf2 and NCK interacting kinase